Fatal Clostridium difficile enteritis caused by the BI/NAP1/027 strain: a case series of ileal C. difficile infections

被引：25

作者：

Lavallee, C. ^{[1
,2
,3
]}

Laufer, B. ^{[3
,4
]}

Pepin, J. ^{[5
]}

Mitchell, A. ^{[3
,6
]}

Dube, S. ^{[3
,7
]}

Labbe, A. -C. ^{[1
,2
,3
]}

机构：

[1] Hop Maison Neuve Rosemont, Dept Microbiol, Montreal, PQ H1T 2M4, Canada

[2] Univ Montreal, Dept Microbiol & Immunol, Montreal, PQ H3C 3J7, Canada

[3] Univ Montreal, Fac Med, Montreal, PQ H3C 3J7, Canada

[4] Hop Maison Neuve Rosemont, Serv Soins Intensifs, Montreal, PQ H1T 2M4, Canada

[5] Univ Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada

[6] Hop Maison Neuve Rosemont, Dept Pathol, Montreal, PQ H1T 2M4, Canada

[7] Hop Maison Neuve Rosemont, Dept Chirurg, Montreal, PQ H1T 2M4, Canada

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2009年 / 15卷 / 12期

关键词：

Autopsy; BI/NAP1/027; strain; Clostridium difficile; colectomy; ileitis; INFLAMMATORY-BOWEL-DISEASE; PSEUDOMEMBRANOUS ENTERITIS; TOXIN; COLECTOMY; PROCTOCOLECTOMY; COLITIS;

D O I：

10.1111/j.1469-0691.2009.03004.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Clostridium difficile generally causes diarrhoea and colitis. Small-bowel infections are considered to be rare. Twelve cases of ileal C difficile infections are presented, including the first reported case proven to be caused by the hypervirulent BI/NAP1/027 strain. This case series suggests that small bowel involvement in C difficile infections may be more frequent than previously thought.

引用

页码：1093 / 1099

页数：7

共 27 条

[1] Clostridium difficile-related necrotizing pseudomembranous enteritis in association with Henoch-Schonlein purpura [J].

Boey, CCM ;

Ramanujam, TM ;

Looi, LM .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1997, 24 (04) :426-429

[2] Clostridium difficile enteritis:: a cause for high ileostomy output [J].

El Muhtaseb, Mohammad Sami H. ;

Apollos, Jeya K. ;

Dreyer, Jacob S. .

ANZ JOURNAL OF SURGERY, 2008, 78 (05) :416-416

[3] Clostridium difficile small bowel enteritis occurring after total colectomy [J].

Freiler, JF ;

Durning, SJ ;

Ender, PT .

CLINICAL INFECTIOUS DISEASES, 2001, 33 (08) :1429-1431

[4] Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters [J].

Geric, B ;

Carman, RJ ;

Rupnik, M ;

Genheimer, CW ;

Sambol, SP ;

Lyerly, DM ;

Gerding, DN ;

Johnson, S .

JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (08) :1143-1150

[5] Ileal perforation secondary to Clostridium difficile enteritis -: Report of 2 cases [J].

Hayetian, FD ;

Read, TE ;

Brozovich, M ;

Garvin, RP ;

Caushaj, PF .

ARCHIVES OF SURGERY, 2006, 141 (01) :97-99

[6] Extracolonic manifestations of Clostridium difficile infections -: Presentation of 2 cases and review of the literature [J].

Jacobs, A ;

Barnard, K ;

Fishel, R ;

Gradon, JD .

MEDICINE, 2001, 80 (02) :88-101

[7] The distribution and density of Clostridium difficile toxin receptors on the intestinal mucosa of neonatal pigs [J].

Keel, M. K. ;

Songer, J. G. .

VETERINARY PATHOLOGY, 2007, 44 (06) :814-822

[8] The comparative pathology of Clostridium difficile-associated disease [J].

Keel, M. K. ;

Songer, J. G. .

VETERINARY PATHOLOGY, 2006, 43 (03) :225-240

[9] NEUTROPHIL RECRUITMENT IN CLOSTRIDIUM-DIFFICILE TOXIN-A ENTERITIS IN THE RABBIT [J].

KELLY, CP ;

BECKER, S ;

LINEVSKY, JK ;

JOSHI, MA ;

OKEANE, JC ;

DICKEY, BF ;

LAMONT, JT ;

POTHOULAKIS, C .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) :1257-1265

[10] Comparison of seven techniques for typing international epidemic strains of Clostfidium difficile:: Restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat analysis, amplified fragment length polymorphism, and surface layer protein A gene sequence typing [J].

Killgore, George ;

Thompson, Angela ;

Johnson, Stuart ;

Brazier, Jon ;

Kuijper, Ed ;

Pepin, Jacques ;

Frost, Eric H. ;

Savelkoul, Paul ;

Nicholson, Brad ;

van den Berg, Renate J. ;

Kato, Haru ;

Sambol, Susan P. ;

Zukowski, Walter ;

Woods, Christopher ;

Limbago, Brandi ;

Gerding, Dale N. ;

McDonald, L. Clifford .

JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (02) :431-437

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