The rs1447295 at 8q24 Is a Risk Variant for Prostate Cancer in Taiwanese Men

被引：17

作者：

Chen, Marcelo ^{[2
,3
,4
]}

Huang, Yu-Chuen ^{[5
]}

Ko, I-ling ^{[1
]}

Yang, Stone ^{[4
,6
]}

Chang, Yen-Hwa ^{[7
]}

Huang, William Ji-Shian ^{[7
]}

Chen, Yi-Ming Arthur ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Inst Microbiol & Immunol, Sch Med, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Div Prevent Med, Inst Publ Hlth, Sch Med, Taipei 112, Taiwan

[3] Hsinchu Mackay Mem Hosp, Dept Urol, Hsinchu, Taiwan

[4] Mackay Coll Nursing & Med, Taipei, Taiwan

[5] China Med Univ Hosp, Dept Med Res, Genet Ctr, Taichung, Taiwan

[6] Taipei Mackay Mem Hosp, Dept Urol, Taipei, Taiwan

[7] Taipei Vet Gen Hosp, Dept Surg, Div Urol, Taipei, Taiwan

来源：

UROLOGY | 2009年 / 74卷 / 03期

关键词：

CHROMOSOME; 8Q24; ASSOCIATION; LOCUS; CONFIRMATION; EPIDEMIOLOGY; POPULATIONS; AMERICANS;

D O I：

10.1016/j.urology.2009.02.035

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES To determine the association of a common variant, rs1447295, at the 8q24 region with prostate cancer (PCa) risk in Taiwanese men. Common variants at the 8q24 region have been shown to be associated with PCa risk. The variant rs1447295 has shown the strongest association. Most of the studies have been performed in European and American populations. METHODS This case-control study comprised 340 PCa patients and 337 controls. Genotyping was performed for rs14417295 to test for the association between its risk allele and PCa. Its association with disease stage, Gleason score, PSA level, and disease aggressiveness was also determined. RESULTS The A allele of rs1447295 was significantly associated with increased PCa risk (odds ratio = 1.49, 95% CI = 1.12-1.99). When compared with controls, the risk allele A was more frequent in PCa patients of both stages I+II (P=.028) and stages III+IV (P=.023), in patients of all Gleason scores (P<.05 in all subgroups), in patients with PSA levels >20 ng/mL (P=.001), and in patients with aggressive disease (P=.005). CONCLUSIONS This study confirmed that the A allele of rs1447295 is associated with a high risk of PCa in Taiwanese men. UROLOGY 74: 698-701, 2009. (C) 2009 Elsevier Inc.

引用

页码：698 / 701

页数：4

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