Depression and the Link with Cardiovascular Disease

被引：281

作者：

Dhar, Arup K. ^{[1
,2
,3
]}

Barton, David A. ^{[1
,2
,3
]}

机构：

[1] Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, Melbourne, Vic, Australia

[2] Alfred Hlth, Alfred Psychiat, Melbourne, Vic, Australia

[3] Monash Univ, Fac Med Nursing & Hlth Sci, Melbourne, Vic 3004, Australia

来源：

FRONTIERS IN PSYCHIATRY | 2016年 / 7卷

关键词：

depression; coronary heart disease; cardiac risk; cardiovascular disease; major depressive disorder; CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; SEROTONIN REUPTAKE INHIBITORS; CARDIAC SYMPATHETIC ACTIVITY; PSYCHOSOCIAL RISK-FACTORS; QUALITY-OF-LIFE; RATE-VARIABILITY; MAJOR DEPRESSION; ARTERY-DISEASE; MENTAL STRESS;

D O I：

10.3389/fpsyt.2016.00033

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This review provides an outline of the association between major depressive disorder (MDD) and coronary heart disease (CHD). Much is known about the two individual clinical conditions; however, it is not until recently, biological mechanisms have been uncovered that link both MDD and CHD. The activation of stress pathways have been implicated as a neurochemical mechanism that links MDD and CHD. Depression is known to be associated with poorer outcomes of CHD. Psychological factors, such as major depression and stress, are now known as risk factors for developing CHD, which is as important and is independent of classic risk factors, such as hypertension, diabetes mellitus, and cigarette smoking. Both conditions have great socioeconomic importance given that depression and CHD are likely to be two of the three leading causes of global burden of disease. Better understanding of the common causal pathways will help us delineate more appropriate treatments.

引用

页数：9

共 121 条

[1] Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: Clinical implications [J].