C-11 methionine uptake in granulomatous disease

Although uptake of F-18 FDG is well documented in granulomatous disease, there is little literature available regarding C-11 methionine positron emission tomography (PET) in these conditions. We present a case in which C-11 methionine imaging was performed for localization of a probable parathyroid adenoma, but other areas of uptake identified were subsequently found to be the result of sarcoidosis. Clinicians must therefore take care when interpreting C-11 methionine PET scans because granulomatous disease could cause false-positives.