Smoking Cessation and Weight Loss After Chronic Deep Brain Stimulation of the Nucleus Accumbens: Therapeutic and Research Implications: Case Report

被引：141
作者：
Mantione, Mariska [1 ]
van de Brink, Wim
Schuurman, P. Richard
Denys, Damiaan
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 AZ Amsterdam, Netherlands
来源：
NEUROSURGERY | 2010年 / 66卷 / 01期
关键词：
Deep brain stimulation; Obesity; Obsessive-compulsive disorder; Reward circuitry; Smoking;
D O I：
10.1227/01.NEU.0000360570.40339.64
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
OBJECTIVE: Smoking and overeating are compulsory habits that are difficult to stop. Several studies have shown involvement of the nucleus accumbens in these and other addictive behaviors. In this case report, we describe a patient who quit smoking and lost weight without any effort, and we review the underlying mechanisms of action. CLINICAL PRESENTATION: A 47-year-old woman presented with chronic treatment-refractory obsessive-compulsive disorder, nicotine dependence, and obesity. INTERVENTION: The patient was treated with deep brain stimulation of the nucleus accumbens for obsessive-compulsive disorder. Unintended, effortless, and simultaneous smoking cessation and weight loss were observed. CONCLUSION:This study supports the idea of compulsivity with common circuitry in the processing of diverse rewards and suggests that deep brain stimulation of the nucleus accumbens could be a possible treatment of patients with a dependency not responding to currently available treatments.
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收藏
页码：218 / 218
页数：1
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