Phytochemical analysis, antioxidant, anticoagulant and in vitro toxicity and genotoxicity testing of methanolic and juice extracts of Beta vulgaris L.

被引：22
作者：
Edziri, H. [1 ]
Jaziri, R. [1 ]
Haddad, O. [1 ]
Anthonissen, R. [2 ]
Aouni, M. [1 ]
Mastouri, M. [3 ]
Verschaeve, L. [2 ,4 ]
机构：
[1] Fac Pharm, Lab Transmissible Dis & Biol Act Subst, Monastir 5000, Tunisia
[2] Sciensano, Risk & Hlth Impact Assessment Serv, J Wytsmanst 14, B-1050 Brussels, Belgium
[3] CHU Fattouma Bouguiba, Lab Microbiol, Monastir 5000, Tunisia
[4] Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
来源：
SOUTH AFRICAN JOURNAL OF BOTANY | 2019年 / 126卷
关键词：
Alkaline comet assay; Anticoagulant activity; Beta vulgaris; Juice; Methanolic extract; Vitotox test; BEETROOT JUICE; PHENOLICS; PLANTS; ASSAY; POLYPHENOLS; RED;
D O I：
10.1016/j.sajb.2019.01.017
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Beet root (Beta vulgaris L.) is well known in cuisine and is also used in traditional medicine to prevent many diseases. We investigated the methanolic extract and juice with respect to the phenolic and flavonoid contents and evaluated their antioxidant, anticoagulant and genotoxic activities. Genotoxicity was studied with the bacterial Vitotox test and the alkaline comet assay involving human C3A liver cells. The methanolic extract had the highest phenolic and flavonoid contents with values of 39.75 mg GAE/g and 20.73 mg CE/g extract, respectively. Methanolic extract and juice showed surprising anticoagulant and antioxidant activities. They were devoid of any genotoxicity or cytotoxic effects. The results show the potential of the plant, especially the juice, as a new source of bioactive molecules for therapeutic purposes, possibly in the treatment of cardiovascular diseases. (C) 2019 SAAB. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：170 / 175
页数：6
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