Targeted Intracellular Delivery of Hydrophobic Agents using Mesoporous Hybrid Silica Nanoparticles as Carrier Systems

被引：197

作者：

Rosenholm, Jessica M. ^{[2
]}

Peuhu, Emilia ^{[1
,3
,4
]}

Eriksson, John E. ^{[1
,3
,4
]}

Sahlgren, Cecilia ^{[1
,3
,4
]}

Linden, Mika ^{[2
]}

机构：

[1] Abo Akad Univ, Dept Biol, FI-20520 Turku, Finland

[2] Abo Akad Univ, Dept Phys Chem, Ctr Funct Mat, FI-20500 Turku, Finland

[3] Univ Turku, Turku Ctr Biotechnol, FI-20521 Turku, Finland

[4] Abo Akad Univ, FI-20521 Turku, Finland

来源：

NANO LETTERS | 2009年 / 9卷 / 09期

基金：

芬兰科学院;

关键词：

WATER-SOLUBLE COMPOUNDS; DRUG-DELIVERY; CONTROLLED-RELEASE; GENE DELIVERY; CELLS;

D O I：

10.1021/nl901589y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Targeted nanoparticle-mediated intracellular delivery is demonstrated using two hydrophobic fluorophores as model drug cargo. The presented hybrid carrier system exhibits both cancer cell-targeting ability and capacity to retain a hydrophobic agent with subsequent specific release into the endosomal compartment. Furthermore, the incorporated agent is shown to be able to escape from the endosomes into the cytoplasm, making the particles promising candidates as carriers for targeted drug delivery for cancer treatment.

引用

页码：3308 / 3311

页数：4

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