Regulation of bone metabolism by the Wnt signaling pathway

被引：4

作者：

Houschyar, K. S. ^{[1
]}

Tapking, C. ^{[2
,3
]}

Duscher, D. ^{[4
]}

Harati, K. ^{[1
]}

Wallner, C. ^{[1
]}

Wagner, J. M. ^{[1
]}

Maan, Z. N. ^{[5
]}

Rein, S. ^{[6
]}

Cheliah, M. P. ^{[5
]}

Reumuth, G. ^{[7
]}

Grieb, G. ^{[8
]}

Siemers, F. ^{[7
]}

Lehnhardt, M. ^{[1
]}

Behr, B. ^{[1
]}

机构：

[1] BG Univ Kliniken Bergmannsheil, Operat Referenzzentrum Gliedmagentumore, Handchirurg Zentrum, Klin Plast Chirurg & Schwerbrandverletzte, Burkle Camp Pl 1, D-44789 Bochum, Germany

[2] Heidelberg Univ, BG Unfallklin Ludwigshafen, Schwerbrandverletztenzentrum, Klin Hand Plast & Rekonstrukt Chirurg, Heidelberg, Germany

[3] Univ Texas Med Branch, Shriners Hosp Children Galveston, Dept Surg, 815 Market St, Galveston, TX 77550 USA

[4] Tech Univ Munich, Klinikum Rechts Isar, Klin Plast Chirurg & Handchirurg, Munich, Germany

[5] Stanford Sch Med, Abt Chirurg, Abt Plast & Rekonstrukt Chirurg, Stanford, CA 94305 USA

[6] Klinikum Sankt Georg, Schwerbrandverletztenzentrum, Klin Plast & Handchirurg, Delitzscher Str 141, D-04129 Leipzig, Germany

[7] Berufsgenossenschaftl Klinikum Bergmannstrost Hal, Klin Plast & Handchirurg, Brandverletztenzentrum, Berlin, Germany

[8] Lehrkrankenhaus Charite Berlin, Gemeinschaftskrankenhaus Havelhohe, Klin Plast Chirurg & Handchirurg, Kladower Damm 221, D-14089 Berlin, Germany

来源：

HANDCHIRURGIE MIKROCHIRURGIE PLASTISCHE CHIRURGIE | 2019年 / 51卷 / 04期

关键词：

Wnt; beta-catenin; regeneration; stem cells; bone; BETA-CATENIN; MINERAL DENSITY; PHOSPHORYLATION; DIFFERENTIATION; PROLIFERATION; OSTEOPOROSIS; INFLAMMATION; OSTEOBLASTS; INHIBITION; ACTIVATION;

D O I：

10.1055/a-0642-1830

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The development and homeostasis of multicellular organisms depends on a complex cellular interaction between proliferation, migration, differentiation, adhesion, and cell death. Wnt signaling pathways coordinate these different cellular responses. Wnt signaling plays a role as a regulatory pathway in the osteogenic differentiation of mesenchymal stem cells. The Wnt signaling pathway is an attractive therapeutic target with the potential to directly modulate stem cells responsible for the regeneration of skeletal tissue. Recent studies indicate that Wnt ligands are capable of promoting bone growth, suggesting that Wnt factors could be used to stimulate bone healing in osteogenic disorders.

引用

页码：309 / 318

页数：10

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