Genetic and phylogenetic characterizations of a novel genotype of highly pathogenic avian influenza (HPAI) H5N8 viruses in 2016/2017 in South Korea

被引：25

作者：

Kim, Young-Il ^{[1
,2
]}

Park, Su-Jin ^{[1
,2
]}

Kwon, Hyeok-Il ^{[1
,2
]}

Kim, Eun-Ha ^{[1
,2
]}

Si, Young-Jae ^{[1
,2
]}

Jeong, Ju-Hwan ^{[1
,2
]}

Lee, In-Won ^{[1
,2
]}

Hiep Dinh Nguyen ^{[1
,2
]}

Kwon, Jin-Jung ^{[1
,2
]}

Choi, Won Suk ^{[1
,2
]}

Song, Min-Suk ^{[1
,2
]}

Kim, Chul-Joong ^{[3
]}

Choi, Young-Ki ^{[1
,2
]}

机构：

[1] Chungbuk Natl Univ, Coll Med, 12 Gaeshin Dong Heungduk Ku, Cheongju 361763, South Korea

[2] Chungbuk Natl Univ, Med Res Inst, 12 Gaeshin Dong Heungduk Ku, Cheongju 361763, South Korea

[3] Chungnam Natl Univ, Coll Vet Med, 220 Gung Dong, Taejon 305764, South Korea

来源：

INFECTION GENETICS AND EVOLUTION | 2017年 / 53卷

关键词：

HPAI H5N8 virus; HPAI H5N6 virus; Reassortant; Migratory birds; South Korea; A VIRUS; A(H5N8) VIRUS; BIRDS; HEMAGGLUTININ; PROTEIN; CHINA;

D O I：

10.1016/j.meegid.2017.05.001

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

During the outbreaks of highly pathogenic avian influenza (HPAI) H5N6 viruses in 2016 in South Korea, novel H5N8 viruses were also isolated from migratory birds. Phylogenetic analysis revealed that the HA gene of these H5N8 viruses belonged to clade 2.3.4.4, similarly to recent H5Nx viruses, and originated from A/Brk/Korea/Gochang1/14(H5N8), a minor lineage of H5N8 that appeared in 2014 and then disappeared. At least four reassortment events occurred with different subtypes (H5N8, H7N7, H3N8 and H10N7) and a chicken challenge study revealed that they were classified as HPAI viruses according to OIE criteria. (C) 2017 Elsevier B.V. All rights reserved.

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收藏

页码：56 / 67

页数：12

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