Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1

被引：90

作者：

Sabio, Guadalupe ^{[1
,2
]}

Cavanagh-Kyros, Julie ^{[1
,2
]}

Barrett, Tamera ^{[1
,2
]}

Jung, Dae Young ^{[2
,3
]}

Ko, Hwi Jin ^{[2
,3
]}

Ong, Helena ^{[2
]}

Morel, Caroline ^{[1
,2
]}

Mora, Alfonso ^{[2
]}

Reilly, Judith ^{[2
]}

Kim, Jason K. ^{[2
,3
,4
]}

Davis, Roger J. ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

[3] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA

[4] Univ Massachusetts, Sch Med, Dept Med, Div Endocrinol Metab & Diabet, Worcester, MA 01605 USA

来源：

GENES & DEVELOPMENT | 2010年 / 24卷 / 03期

基金：

美国国家卫生研究院;

关键词：

JNK1; obesity; insulin resistance; thyroid hormone; INSULIN-RESISTANCE; PATHWAY; OBESITY; GENE;

D O I：

10.1101/gad.1878510

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obesity. Here we demonstrate that selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. The failure to increase body mass is mediated, in part, by increased energy expenditure that is associated with activation of the hypothalamic-pituitary-thyroid axis. Disruption of thyroid hormone function prevents the effects of nervous system JNK1 deficiency on body mass. These data demonstrate that the hypothalamic-pituitary-thyroid axis represents an important target of metabolic signaling by JNK1.

引用

页码：256 / 264

页数：9

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