Lipid vesicles for skin delivery of drugs: Reviewing three decades of research

被引：405
|
作者：
Elsayed, Mustafa M. A. [1 ]
Abdallah, Ossama Y. [1 ]
Naggar, Viviane F. [1 ]
Khalafallah, Nawal M. [1 ]
机构：
[1] Univ Alexandria, Fac Pharm, Dept Pharmaceut, Alexandria 21521, Egypt
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2007年 / 332卷 / 1-2期
关键词：
lipid vesicles; liposomes; deformable liposomes; ethosomes; skin delivery; topical; transdermal; mechanism of action;
D O I：
10.1016/j.ijpharm.2006.12.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Since liposomes were first shown to be of potential value for topical therapy by Mezei and Gulasekharam in 1980, studies continued towards further investigation and development of lipid vesicles as carriers for skin delivery of drugs. Despite this long history of intensive research, lipid vesicles are still considered as a controversial class of dermal and transdermal carriers. Accordingly, this article provides an overview of the development of lipid vesicles for skin delivery of drugs, with special emphasis on recent advances in this field, including the development of deformable liposomes and ethosomes. (c) 2006 Elsevier B.V. All rights reserved.
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页码：1 / 16
页数：16
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