Nickel-catalysed para-CH activation of pyridine with switchable regioselective hydroheteroarylation of allylarenes

被引：72

作者：

Lee, Wei-Chih ^{[1
]}

Chen, Chien-Hung ^{[1
,2
]}

Liu, Cheng-Yuan ^{[1
]}

Yu, Ming-Shiuan ^{[1
]}

Lin, Yung-Huei ^{[1
]}

Ong, Tiow-Gan ^{[1
,2
]}

机构：

[1] Acad Sinica, Inst Chem, Taipei, Taiwan

[2] Natl Chiao Tung Univ, Dept Appl Chem, Hsinchu 300, Taiwan

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 96期

关键词：

RH(I)-CATALYZED DIRECT ARYLATION; SELECTIVE ALKENYLATION; BOND ACTIVATION; H ACTIVATION; ALKYLATION;

D O I：

10.1039/c5cc07455j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

para-CH activation of pyridine with allylbenzene is described by Ni/Al cooperative catalysis in combination with a bulkier NHC ligand and a Lewis acid, leading to linear hydroheteroarylation products. Interestingly, the branch selectivity can be achieved by using the combination of a less sterically hindered amino-NHC ligand and AlMe3 through tandem reaction of facile alkene isomerization followed by a slow CH bond activation process.

引用

收藏

页码：17104 / 17107

页数：4

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