Prognostic Value of Third Cervical Vertebra Skeletal Muscle Index in Oral Cavity Cancer: A Retrospective Study

被引：15
作者：
Chang, Sheng-Wei [1 ]
Hsu, Cheng-Ming [2 ]
Tsai, Yuan-Hsiung [1 ]
Chang, Geng-He [2 ]
Tsai, Ming-Shao [2 ]
Huang, Ethan I. [2 ]
Tsai, Yao-Te [2 ]
机构：
[1] Chang Gung Mem Hosp, Dept Radiol, Chiayi, Taiwan
[2] Chang Gung Mem Hosp, Dept Otorhinolaryngol Head & Neck Surg, 6 W Sec,Jiapu Rd, Chiayi 61363, Taiwan
来源：
LARYNGOSCOPE | 2021年 / 131卷 / 07期
关键词：
Oral cavity; radiology; outcomes; LOCALLY ADVANCED HEAD; NECK-CANCER; CLINICAL-IMPLICATIONS; BODY-COMPOSITION; SURVIVAL; MASS; MALNUTRITION; SARCOPENIA; INFLAMMATION; PREVALENCE;
D O I：
10.1002/lary.29390
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objectives/Hypothesis To assess the prognostic utility of third cervical vertebra skeletal muscle index (C3 SMI) measured from preoperative head and neck computed tomography (CT) in patients with oral cavity squamous cell carcinoma (OSCC). Study Design Retrospective study. Methods We retrospectively reviewed the medical records of 125 patients who underwent primary curative surgery for OSCC between 2009 and 2017. Their preoperative C3 SMI was calculated by adjusting the C3 cross-sectional area delineated on head and neck CT by body height squared. A Cox proportional hazard model was employed to identify prognostic factors, and a novel nomogram based on C3 SMI was built for individualized survival prediction. Results In Kaplan-Meier analysis, high C3 SMI was significantly associated with higher 5-year disease-free survival (DFS) and overall survival (OS) than low C3 SMI. In multivariate analysis, low C3 SMI was an independent risk factor for poor DFS and OS (hazard ratio [HR]: 2.197; 95% confidence interval [CI], 1.170-4.512, P = .032 and HR: 2.143; 95% CI, 1.232-3.728, P = .007, respectively). The concordance-index (C-index) of the nomogram based on C3 SMI was 0.814 for OS, higher than that of the nomogram based on tumor-node-metastasis staging alone (C-index = 0.731). Conclusions C3 SMI might serve as a novel prognosticator in OSCC patients undergoing curative surgery, and the nomogram based on C3 SMI might provide good prognostic discrimination ability for individualized survival prediction. Level of Evidence IV Laryngoscope, 2021
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页码：E2257 / E2265
页数：9
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