Faecal calprotectin concentrations and diagnosis of necrotising enterocolitis

被引：106

作者：

Carroll, D ^{[1
]}

Corfield, A ^{[1
]}

Spicer, R ^{[1
]}

Cairns, P ^{[1
]}

机构：

[1] Royal Hosp Sick Children, Dept Paediat Surg, Bristol BS2 8BJ, Avon, England

来源：

LANCET | 2003年 / 361卷 / 9354期

关键词：

D O I：

10.1016/S0140-6736(03)12333-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Calprotectin has been proposed as a useful marker of inflammatory bowel disease in children. We did a pilot study to establish whether it can be used to aid diagnosis of necrotising enterocolitis in preterm infants. Patients with clinical features of necrotising enterocolitis had raised faecal calprotectin concentrations at the time of diagnosis compared with matched controls (288.4 mg/L [SD 49.1] and 98.0 mg/L [60.6], respectively; p=0.0006). Faecal calprotectin might be a useful marker of gastrointestinal mucosal inflammation in neonates.

引用

页码：310 / 311

页数：2

共 5 条

[1]

Fagerhol M. K., 1990, STIMULUS RESPONSE CO, P187

[2] Calprotectin, a faecal marker of organic gastrointestinal abnormality [J].

Fagerhol, MK .

LANCET, 2000, 356 (9244) :1783-1784

[3] Faecal calprotectin levels in infants with infantile colic, healthy infants, children with inflammatory bowel disease, children with recurrent abdominal pain and healthy children [J].

Olafsdottir, E ;

Aksnes, L ;

Fluge, G ;

Berstad, A .

ACTA PAEDIATRICA, 2002, 91 (01) :45-50

[4]

Rugtveit J, 2002, J PEDIATR GASTR NUTR, V34, P323, DOI 10.1097/00005176-200203000-00022

[5] A simple method for assessing intestinal inflammation in Crohn's disease [J].

Tibble, J ;

Teahon, K ;

Thjodleifsson, B ;

Roseth, A ;

Sigthorsson, G ;

Bridger, S ;

Foster, R ;

Sherwood, R ;

Fagerhol, M ;

Bjarnason, I .

GUT, 2000, 47 (04) :506-513

← 1 →