Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin

被引：64

作者：

Geusau, A

Tschachler, E

Meixner, M

Sandermann, S

Päpke, O

Wolf, C

Valic, E

Stingl, G

McLachlan, M ^{[1
]}

机构：

[1] Baltic Sea Res Inst, D-18112 Rostock, Germany

[2] Univ Vienna, Sch Med, Dept Dermatol, Div Immunol Allergy & Infect Dis, A-1010 Vienna, Austria

[3] Univ Vienna, Sch Med, Dept Med, Div Occupat Med, A-1010 Vienna, Austria

[4] ERGO Forsch Gesell, Hamburg, Germany

来源：

LANCET | 1999年 / 354卷 / 9186期

关键词：

D O I：

10.1016/S0140-6736(99)04271-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two patients with chloracne had concentrations of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) of 144 000 and 26 000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years.

引用

页码：1266 / 1267

页数：2

共 5 条

[1] Intake, fecal excretion, and body burden of polychlorinated dibenzo-p-dioxins and dibenzofurans in breast-fed and formula-fed infants [J].