Serum Levels of IL-6, IL-8, TNF-α, and TGF-β in Chronic HBV-Infected Patients: Effect of Depression and Anxiety

被引：21

作者：

Bahramabadi, Reza ^{[1
,2
]}

Fathollahi, Mahmood Sheikh ^{[1
,3
]}

Hashemi, Seyyed Mohammad ^{[4
]}

Arababadi, Amin Safari ^{[1
]}

Arababadi, Minoo Safari ^{[1
]}

Yousefi-Daredor, Hassan ^{[1
]}

Bidaki, Reza ^{[5
,6
]}

Khaleghinia, Mehdi ^{[7
]}

Bakhshi, Mohammad Hossein ^{[1
]}

Yousefpoor, Yaser ^{[4
]}

Torbaghan, Yaser Eskandari ^{[4
]}

Arababadi, Mohammad Kazemi ^{[1
,2
]}

机构：

[1] Rafsanjan Univ Med Sci, Med Sch, Immunol Infect Dis Res Ctr, Rafsanjan, Iran

[2] Rafsanjan Univ Med Sci, Med Sch, Fac Med, Dept Immunol, Rafsanjan, Iran

[3] Rafsanjan Univ Med Sci, Med Sch, Dept Epidemiol & Biostat, Rafsanjan, Iran

[4] Mashhad Univ Med Sci, Khalil Abad Hlth Ctr, Mashhad, Iran

[5] Shahid Sadoughi Univ Med Sci, Res Ctr Addict & Behav Sci, Yazd, Iran

[6] Shahid Sadoughi Univ Med Sci, Diabet Res Ctr, Yazd, Iran

[7] Kerman Univ Med Sci, Med Sch, Dept Infect Dis, Kerman, Iran

来源：

LABORATORY MEDICINE | 2018年 / 49卷 / 01期

关键词：

psychiatric diseases; chronic HBV infection; IL-6; IL-8; TGF-beta; TNF-alpha; CHRONIC HEPATITIS-B; PROFILE;

D O I：

10.1093/labmed/lmx064

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: To assess the effects of depression and anxiety on serum cytokine levels in patients with chronic hepatitis B (CHB) infection. Methods: In this cross-sectional study, 60 healthy control individuals and 60 patients with CHB participated after filling out standard questionnaires. We examined their serum interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, and TGF-beta levels using enzyme-linked immunosorbent assay (ELISA) techniques. Results: In patients with CHB compared with healthy controls, serum levels of IL-8 were significantly increased, whereas IL-6 and TGF-beta levels were significantly decreased. Serum levels of TGF-beta were significantly decreased in the patients with CHB who had mild depression, compared with patients with CHB without depression and with moderate and severe depression. Conclusions: Downregulation of IL-8 and TGF-beta, respectively, is a corresponding mechanism for induction of chronic inflammation in patients with CHB. Depression also seems to induce inflammation via downregulation of TGF-beta in these patients.

引用

页码：41 / 46

页数：6

共 17 条

[1] The IL-10 Promoter Polymorphism at Position-592 is Correlated with Susceptibility to Occult HBV Infection [J].

Ahmadabadi, Behzad Nasiri ;

Hassanshahi, Gholamhossein ;

Arababadi, Mohammad Kazemi ;

Leanza, Cristiana ;

Kennedy, Derek .

INFLAMMATION, 2012, 35 (03) :818-821

[2]

Arslan N, 2003, TURKISH J PEDIATR, V45, P26

[3] SCREENING DEPRESSED PATIENTS IN FAMILY PRACTICE - RAPID TECHNIQUE [J].

BECK, AT ;

BECK, RW .

POSTGRADUATE MEDICINE, 1972, 52 (06) :81-&

[4] Chronic hepatitis B in Asia-new insights from the past decade [J].

Chan, Henry Lik-Yuen ;

Jia, Jidong .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2011, 26 :131-137

[5] TGF-β1-induced regulatory T cells [J].

Hadaschik, Eva N. ;

Enk, Alexander H. .

HUMAN IMMUNOLOGY, 2015, 76 (08) :561-564

[6] The adapter proteins of TLRs, TRIF and MYD88, are upregulated in depressed individuals [J].

Hajebrahimi, Batool ;

Bagheri, Masoud ;

Hassanshahi, Gholamhossein ;

Nazari, Mahmood ;

Bidaki, Reza ;

Khodadadi, Hassan ;

Arababadi, Mohammad Kazemi ;

Kennedy, Derek .

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 2014, 18 (01) :41-44

[7] Important roles played by TGF-β in hepatitis B infection [J].

Karimi-Googheri, Masoud ;

Daneshvar, Hamid ;

Nosratabadi, Reza ;

Zare-Bidaki, Mohammad ;

Hassanshahi, Gholamhossein ;

Ebrahim, Maryam ;

Arababadi, Mohammad Kazemi ;

Kennedy, Derek .

JOURNAL OF MEDICAL VIROLOGY, 2014, 86 (01) :102-108

[8] High Serum Levels of TGF-β in Iranians With Chronic HBV Infection [J].

Khorramdelazad, Hossein ;

Hassanshahi, Gholamhossein ;

Ahmadabadi, Behzad Nasiri ;

Arababadi, Mohammad Kazemi .

HEPATITIS MONTHLY, 2012, 12 (11)

[9] Approach to discriminate subgroups in multiple sclerosis with cerebrospinal fluid (CSF) basic inflammation indices and TNF-α, IL-1β, IL-6, IL-8 [J].

Kleine, TO ;

Zwerenz, P ;

Graser, C ;

Zöfel, P .

BRAIN RESEARCH BULLETIN, 2003, 61 (03) :327-346

[10] The high prevalence of the I27 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope [J].

Liu, Heng-Gui ;

Chen, Wei-wei ;

Fan, Zhen-Ping ;

Yang, Hui-ying ;

Shi, Ming ;

Zhang, Zheng ;

Luan, Shen-Shun ;

Zhang, Hui ;

Lu, Peng ;

Tien, Po ;

Wang, Fu-Sheng .

CLINICAL IMMUNOLOGY, 2007, 125 (03) :337-345

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