Application of attenuated total reflectance Fourier transform infrared spectroscopy for determination of cefixime in oral pharmaceutical formulations

被引：21

作者：

Kandhro, Aftab A. ^{[1
]}

Laghari, Abdul Hafeez ^{[1
]}

Mahesar, Sarfaraz A. ^{[2
]}

Saleem, Rubina ^{[1
]}

Nelofar, Aisha ^{[1
]}

Khan, Salman Tariq ^{[1
]}

Sherazi, S. T. H. ^{[2
]}

机构：

[1] Pakistan Council Sci & Ind Res Labs Complex, Karachi, Sindh, Pakistan

[2] Univ Sindh, Natl Ctr Excellence Analyt Chem, Jamshoro, Sindh, Pakistan

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2013年 / 115卷

关键词：

Cefixime; FT-IR; Diamond cell-ATR; PLS; Quality control; HPLC; PARTIAL LEAST-SQUARE; FT-IR SPECTROSCOPY; DOSAGE FORMS; EDIBLE OILS;

D O I：

10.1016/j.saa.2013.06.032

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A quick and reliable analytical method for the quantitative assessment of cefixime in orally administered pharmaceutical formulations is developed by using diamond cell attenuated total reflectance (ATR) Fourier transform infrared (FT-IR) spectroscopy as an easy procedure for quality control laboratories. The standards for calibration were prepared in aqueous medium ranging from 350 to 6000 mg/kg. The calibration model was developed based on partial least square (PLS) using finger print region of FT-IR spectrum in the range from 1485 to 887 cm(-1). Excellent coefficient of determination (R-2) was achieved as high as 0.99976 with root mean square error of 44.8 for calibration. The application of diamond cell (smart accessory) ATR FT-IR proves a reliable determination of cefixime in pharmaceutical formulations to assess the quality of the final product. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：51 / 56

页数：6

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