Enantioselective Epoxidation of β,β-Disubstituted Enamides with a Manganese Catalyst and Aqueous Hydrogen Peroxide

被引：18
作者：
Claraso, Carlota [1 ,2 ]
Vicens, Laia [1 ,2 ]
Polo, Alfonso [1 ]
Costas, Miquel [1 ,2 ]
机构：
[1] Univ Girona, Dept Quim, Campus Montilivi, E-17003 Girona, Catalonia, Spain
[2] Univ Girona, IQCC, E-17003 Girona, Catalonia, Spain
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 07期
关键词：
NONHEME IRON-CATALYSTS; ASYMMETRIC EPOXIDATION; C-H; BOND OXIDATION; OLEFINS; COMPLEXES; H2O2; ALKENES; ENONES; AZIRIDINATION;
D O I：
10.1021/acs.orglett.9b00729
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enantioselective epoxidation of beta,beta-disubstituted enamides with aqueous hydrogen peroxide and a novel manganese catalyst is described. Epoxidation is stereospecific and proceeds fast under mild conditions. Amides are disclosed as key functional groups to enable high enantioselectivity.
引用
收藏
页码：2430 / 2435
页数：6
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