Tropomyosins in the healthy and diseased nervous system

被引：20
作者：
Brettle, Merryn [1 ]
Patel, Shrujna [1 ]
Fath, Thomas [1 ]
机构：
[1] Univ New South Wales, Sch Med Sci, Neurodegenerat & Repair Unit, Sydney, NSW 2052, Australia
来源：
BRAIN RESEARCH BULLETIN | 2016年 / 126卷
基金：
英国医学研究理事会;
关键词：
Actin cytoskeleton; Tropomyosin; Neurite outgrowth; Central nervous system; Regeneration; PHOSPHATE-ACTIVATED GLUTAMINASE; AMYOTROPHIC-LATERAL-SCLEROSIS; BUNDLING PROTEIN FASCIN; ACTIN-FILAMENT FUNCTION; TRAUMATIC BRAIN-INJURY; LONG-TERM POTENTIATION; DENDRITIC SPINES; SYNAPTIC PLASTICITY; ALZHEIMERS-DISEASE; ARP2/3; COMPLEX;
D O I：
10.1016/j.brainresbull.2016.06.004
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Regulation of the actin cytoskeleton is dependent on a plethora of actin-associated proteins in all eukaryotic cells. The family of tropomyosins plays a key role in controlling the function of several of these actin-associated proteins and their access to actin filaments. In order to understand the regulation of the actin cytoskeleton in highly dynamic subcellular compartments of neurons such as growth cones of developing neurons and the synaptic compartment of mature neurons, it is pivotal to decipher the functional role of tropomyosins in the nervous system. In this review, we will discuss the current understanding and recent findings on the regulation of the actin cytoskeleton by tropomyosins and potential implication that this has for the dysregulation of the actin cytoskeleton in neurological diseases. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：311 / 323
页数：13
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