Myeloid-Derived Suppressor Cells in Colorectal Cancer

被引：79

作者：

Sieminska, Izabela ^{[1
]}

Baran, Jarek ^{[1
]}

机构：

[1] Jagiellonian Univ Med Coll, Dept Clin Immunol, Krakow, Poland

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

基金：

欧盟地平线“2020”;

关键词：

colorectal cancer (CRC); myeloid-derived suppressor cells (MDSCs); inducible NO synthase (iNOS); arginase-1 (ARG1); T regulatory cells (Tregs); STAT3; ACTIVATION; PROMOTES ANGIOGENESIS; NITRIC-OXIDE; COLON-CANCER; TUMOR-CELLS; ARGINASE-I; TGF-BETA; T-CELLS; DIFFERENTIATION; GROWTH;

D O I：

10.3389/fimmu.2020.01526

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Colorectal cancer (CRC) remains one of the most common malignancies diagnosed worldwide. The pathogenesis of CRC is complex and involves, among others, accumulation of genetic predispositions and epigenetic factors, dietary habits, alterations in gut microbiota, and lack of physical activity. A growing body of evidence suggests that immune cells play different roles in CRC, comprising both pro- and anti-tumorigenic functions. Immunosuppression observed during cancer development and progression is a result of the orchestration of many cell types, including myeloid-derived suppressor cells (MDSCs). MDSCs, along with other cells, stimulate tumor growth, angiogenesis, and formation of metastases. This article focuses on MDSCs in relation to their role in the initiation and progression of CRC. Possible forms of immunotherapies targeting MDSCs in CRC are also discussed.

引用

页数：10

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