functional MRI;
morality;
theory of mind;
TEMPORO-PARIETAL JUNCTION;
VOXEL PATTERN-ANALYSIS;
LANGUAGE COMPREHENSION;
SOCIAL COGNITION;
AUTISM;
FMRI;
MIND;
SPECTRUM;
BRAIN;
CHILDREN;
D O I:
10.1073/pnas.1207992110
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Intentional harms are typically judged to be morally worse than accidental harms. Distinguishing between intentional harms and accidents depends on the capacity for mental state reasoning (i.e., reasoning about beliefs and intentions), which is supported by a group of brain regions including the right temporo-parietal junction (RTPJ). Prior research has found that interfering with activity in RTPJ can impair mental state reasoning for moral judgment and that high-functioning individuals with autism spectrum disorders make moral judgments based less on intent information than neurotypical participants. Three experiments, using multivoxel pattern analysis, find that (i) in neurotypical adults, the RTPJ shows reliable and distinct spatial patterns of responses across voxels for intentional vs. accidental harms, and (ii) individual differences in this neural pattern predict differences in participants' moral judgments. These effects are specific to RTPJ. By contrast, (iii) this distinction was absent in adults with autism spectrum disorders. We conclude that multivoxel pattern analysis can detect features of mental state representations (e. g., intent), and that the corresponding neural patterns are behaviorally and clinically relevant.
机构:
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Kennedy, Daniel P.
;
Courchesne, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Rady Childrens Hosp, Res Ctr, Ctr Autism Res, La Jolla, CA 92037 USAUniv Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
机构:
Calif State Univ San Bernardino, Dept Psychol, San Bernardino, CA 92407 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
Koshino, Hideya
;
Kana, Rajesh K.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
Kana, Rajesh K.
;
Keller, Timothy A.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
Keller, Timothy A.
;
Cherkassky, Vladimir L.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
Cherkassky, Vladimir L.
;
Minshew, Nancy J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
Minshew, Nancy J.
;
Just, Marcel Adam
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
机构:
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Kennedy, Daniel P.
;
Courchesne, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Rady Childrens Hosp, Res Ctr, Ctr Autism Res, La Jolla, CA 92037 USAUniv Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
机构:
Calif State Univ San Bernardino, Dept Psychol, San Bernardino, CA 92407 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
Koshino, Hideya
;
Kana, Rajesh K.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
Kana, Rajesh K.
;
Keller, Timothy A.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
Keller, Timothy A.
;
Cherkassky, Vladimir L.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
Cherkassky, Vladimir L.
;
Minshew, Nancy J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA
Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA
Minshew, Nancy J.
;
Just, Marcel Adam
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USACarnegie Mellon Univ, Dept Psychol, Ctr Cognit Brain Imaging, Pittsburgh, PA 15213 USA