Prevalence of complex sleep apnea among Japanese patients with sleep apnea syndrome

被引:34
作者
Endo, Yuri [2 ]
Suzuki, Masaaki [1 ,3 ]
Inoue, Yuichi [4 ,5 ]
Sato, Mitsuo [6 ]
Namba, Kazuyoshi [4 ]
Hasegawa, Makoto [6 ]
Matsuura, Masato [2 ]
机构
[1] Teikyo Univ, Sch Med, Dept Otolaryngol, Itabashi Ku, Tokyo 1738605, Japan
[2] Tokyo Med & Dent Univ, Grad Sch Hlth Sci, Dept Life Sci & Bioinformat, Tokyo, Japan
[3] Ikebukuro Sleep Clin, Div Sleep Med, Tokyo, Japan
[4] Japan Somnol Ctr, Neuropsychiat Res Inst, Tokyo, Japan
[5] Tokyo Med Univ, Dept Psychiat, Tokyo, Japan
[6] Tokyo Med & Dent Univ, Grad Sch, Dept Sleep Related Resp Disorders, Tokyo, Japan
关键词
obstructive sleep apnea syndrome; central sleep apnea syndrome; hypertension; cardiac disease; cerebrovascular disease;
D O I
10.1620/tjem.215.349
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sleep apnea syndrome (SAS) is basically divided into two types: obstructive and central SAS. Recently, the concept of complex SAS has been advocated. Complex SAS is defined as SAS that initially manifests as primarily obstructive SAS, but is characterized by the frequent central apneas after the removal of upper airway obstruction. To determine the prevalence and clinical significance of complex SAS among Japanese patients with SAS, 1,312 patients with SAS were enrolled in this study. Diagnosis of central SAS was made based on diagnostic polysomnography, and differentiation of obstructive SAS from complex SAS was made from polysomnographic findings for treatment with continuous positive airway pressure, which resolved upper airway obstruction. As a result, obstructive SAS was found in 1,232 of 1,312 patients with SAS (93.9%) and central SAS was found in 14 patients (1.1%). The overall prevalence of complex SAS was 5.0% (n = 66). The prevalence of complex SAS among 1,218 male and 94 female patients with SAS were 5.3% and 1.1%, respectively. Patients with complex SAS had significantly higher apnea/hypopnea indices than patients with either obstructive or central SAS, but were similar in both mean age and average body mass index to obstructive SAS patients. There were no significant between-group differences in numbers of patients with clinical complications including hypertension, cardiac diseases, or cerebrovascular diseases. In conclusion, the prevalence of complex SAS in Japanese SAS patients is 5.0%, which is lower than previously reported prevalence of complex SAS in the USA and Australia.
引用
收藏
页码:349 / 354
页数:6
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