Danger-associated metabolic modifications during bacterial infection of macrophages

被引：5
|
作者：
Drame, Mariatou [1 ,2 ,3 ]
Buchrieser, Carmen [1 ,2 ]
Escoll, Pedro [1 ,2 ]
机构：
[1] Inst Pasteur, Unite Biol Bacteries Intracellulaires, 28 Rue Dr Roux, F-75015 Paris, France
[2] CNRS, UMR 3525, F-75015 Paris, France
[3] Sorbonne Univ, F-75006 Paris, France
来源：
INTERNATIONAL IMMUNOLOGY | 2020年 / 32卷 / 07期
关键词：
DAMM; glycolysis; immunometabolism; intracellular bacteria; OXPHOS; NLRP3 INFLAMMASOME ACTIVATION; MITOCHONDRIAL DYNAMICS; IMMUNOMETABOLISM; EPIDEMIOLOGY; IL-1-BETA; HEXOKINASE; MECHANISMS; GLYCOLYSIS; PYROPTOSIS; SUCCINATE;
D O I：
10.1093/intimm/dxaa035
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this review, we propose that certain modifications in cellular metabolism might function as danger signals triggering inflammasome-mediated immune responses. We propose to call them danger-associated metabolic modifications (DAMMs). As intracellular bacteria can actively modulate macrophage metabolism for their benefit, infected host cells might sense bacteria-induced metabolic alterations and activate immune reactions. Here we report the known metabolic interactions that occur during infection of macrophages by intracellular bacteria and discuss the possible emergence of DAMMs upon bacteria-induced alterations of cellular metabolism.
引用
收藏
页码：475 / 483
页数：9
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