Cardiovascular calcifications after radiation therapy for Hodgkin lymphoma: computed tomography detection and clinical correlation

被引:27
作者
Apter, Sara [1 ]
Shemesh, Joseph
Raanani, Pia
Portnov, Orith
Thaler, Michael
Zissin, Rivka
Ezra, David
Rozenman, Judith
Pfeffer, Raphael
Hertz, Marjorie
机构
[1] Chaim Sheba Med Ctr, Dept Diagnost Imaging, IL-52621 Tel Hashomer, Israel
[2] Chaim Sheba Med Ctr, Cardiac Rehabil Inst, IL-52621 Tel Hashomer, Israel
[3] Chaim Sheba Med Ctr, Inst Hematol, IL-52621 Tel Hashomer, Israel
[4] Chaim Sheba Med Ctr, Dept Med, IL-52621 Tel Hashomer, Israel
[5] Chaim Sheba Med Ctr, Inst Oncol, IL-52621 Tel Hashomer, Israel
[6] Sapir Med Ctr, Dept Diagnost Imaging, Kefar Sava, Israel
关键词
D O I
10.1097/00019501-200603000-00008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To study cardiovascular calcifications, detected by computed tomogrpahy, in patients following mediastinal radiation for Hodgkin lymphoma, and correlate them with clinical findings. Fifteen patients, <= 55 years, with computed tomography detected cardiovascular calcifications after mediastinal radiotherapy for Hodgkin lymphoma were identified during a 10-year period. Calcifications were evaluated for site and extent and were correlated with clinical data including symptoms and signs of heart disease, angiographic and surgical findings. Accelerated calcifications were detected in the coronary arteries (n = 11), in the aorta (n = 11), and in the aortic valve and the mitral apparatus (n = 8). Calcifications were more extensive when radiation was given at a young age. Clinical evidence of cardiovascular disease included coronary events in three patients, valvular dysfunction in two, pericarditis in two and complete atrioventricular block in one. Seven patients had no cardiac symptoms. Early cardiovascular calcifications can be radiation associated. Such calcifications may represent radiation induced atherosclerosis and can be detected by computer tomography even in asypmtomatic patients. The implication of our findings is that spiral computed tomography may serve as a non-invasive modality to detect accelerated cardiovascular calcifications in high-risk asymptomatic patients who survived Hodgkin lymphoma.
引用
收藏
页码:145 / 151
页数:7
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