Circulating tumor cells in breast cancer

被引：20

作者：

Banys, Malgorzata ^{[1
,5
]}

Mueller, Volkmar ^{[2
]}

Melcher, Carola ^{[3
]}

Aktas, Bahriye ^{[4
]}

Kasimir-Bauer, Sabine ^{[4
]}

Hagenbeck, Carsten ^{[3
]}

Hartkopf, Andreas ^{[1
]}

Fehm, Tanja ^{[3
]}

机构：

[1] Univ Tubingen, Dept Obstet & Gynecol, Tubingen, Germany

[2] Univ Hamburg, Dept Gynecol, Hamburg, Germany

[3] Univ Duesseldorf, Dept Obstet & Gynecol, Dusseldorf, Germany

[4] Univ Duisburg Essen, Univ Hosp Essen, Dept Gynecol & Obstet, Duisburg, Germany

[5] Marien Hosp, Dept Gynecol & Obstet, Hamburg, Germany

来源：

CLINICA CHIMICA ACTA | 2013年 / 423卷

关键词：

Breast cancer; Disseminated tumor cell; Circulating tumor cell; Prognosis; Biomarkers; RNA-POSITIVE CELLS; TIME RT-PCR; BONE-MARROW; PERIPHERAL-BLOOD; NEOADJUVANT CHEMOTHERAPY; EPITHELIAL-CELLS; PROGNOSTIC-SIGNIFICANCE; HER2; STATUS; PREDICTIVE-VALUE; POOLED ANALYSIS;

D O I：

10.1016/j.cca.2013.03.029

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Detection of disseminated tumor cells (DTCs) in bone marrow and of circulating tumor cells (CTCs) in the blood has become a major focus of translational cancer research. DTC presence is a common phenomenon seen in 30-40% of primary breast cancer patients and is strongly associated with poor clinical outcome. Since bone marrow biopsy is an invasive procedure, evaluation of CTCs might become a desired alternative. Recent clinical trials have shown CTC detection to be a promising prognostic tool in both primary and metastatic setting. Evaluation of CTCs might be useful for therapy monitoring and their characterization might help to identify novel targets for biological therapies aimed at disrupting earliest steps of metastatic cascade. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：39 / 45

页数：7

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