共 19 条
Characterization of intrinsic variability in time-series metabolomic data of cultured mammalian cells
被引:4
作者:

Le, Huong
论文数: 0 引用数: 0
h-index: 0
机构:
Amgen Inc, Proc Dev, Drug Substance Technol, Thousand Oaks, CA 91320 USA Amgen Inc, Proc Dev, Drug Substance Technol, Thousand Oaks, CA 91320 USA

Jerums, Matthew
论文数: 0 引用数: 0
h-index: 0
机构:
Amgen Inc, Proc Dev, Drug Substance Technol, Thousand Oaks, CA 91320 USA Amgen Inc, Proc Dev, Drug Substance Technol, Thousand Oaks, CA 91320 USA

Goudar, Chetan T.
论文数: 0 引用数: 0
h-index: 0
机构:
Amgen Inc, Proc Dev, Drug Substance Technol, Thousand Oaks, CA 91320 USA Amgen Inc, Proc Dev, Drug Substance Technol, Thousand Oaks, CA 91320 USA
机构:
[1] Amgen Inc, Proc Dev, Drug Substance Technol, Thousand Oaks, CA 91320 USA
关键词:
biological variance;
technical variance;
metabolomics;
cell culture;
CHO cells;
time-series;
PROFILING REVEALS;
CHO-CELLS;
D O I:
10.1002/bit.25646
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
In an attempt to rigorously characterize the intrinsic variability associated with Chinese Hamster Ovary (CHO) cell metabolomics studies, supernatant and intracellular samples taken at 5 time points from duplicate lab-scale bioreactors were analyzed using a combination of gas chromatography (GC)- and liquid chromatography-mass spectrometry (LC-MS) based metabolomics. The intrinsic variability between them was quantified using the relative standard deviation (RSD), and the median RSD was 9.4% and 12.4% for supernatant and intracellular samples, respectively. When exploring metabolic changes between lab- and pilot-scale bioreactors, a high number of metabolites (65-105) were significantly different when no corrections were made for this intrinsic variability. This distinction also extended to principal component and metabolic pathway analysis. However, when intrinsic variability was taken into account, the number of metabolite with significant changes reduced substantially (20-25) as did the separation in principal component and metabolic pathway analysis, suggesting a much smaller change in physiology across bioreactor scale. Our results also suggested the contribution of biological variability to the total variability across replicates (approximate to 0.4%) was significantly lower than that from technical variability (approximate to 9-12%). Our study highlights the need for understanding and accounting for intrinsic variability in CHO cell metabolomics studies. Failure to do so can result in incorrect biological interpretation of the observations which could ultimately lead to the identification of a suboptimal set of targets for genetic engineering or process development considerations. Biotechnol. Bioeng. 2015;112: 2276-2283. (c) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:2276 / 2283
页数:8
相关论文
共 19 条
[1]
Metabolite profiling reveals new insights into the regulation of serum urate in humans
[J].
Albrecht, Eva
;
Waldenberger, Melanie
;
Krumsiek, Jan
;
Evans, Anne M.
;
Jeratsch, Ulli
;
Breier, Michaela
;
Adamski, Jerzy
;
Koenig, Wolfgang
;
Zeilinger, Sonja
;
Fuchs, Christiane
;
Klopp, Norman
;
Theis, Fabian J.
;
Wichmann, H. -Erich
;
Suhre, Karsten
;
Illig, Thomas
;
Strauch, Konstantin
;
Peters, Annette
;
Gieger, Christian
;
Kastenmueller, Gabi
;
Doering, Angela
;
Meisinger, Christa
.
METABOLOMICS,
2014, 10 (01)
:141-151

Albrecht, Eva
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Waldenberger, Melanie
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Krumsiek, Jan
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Bioinformat & Syst Biol, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Evans, Anne M.
论文数: 0 引用数: 0
h-index: 0
机构:
Metabolon Inc, Durham, NC 27713 USA Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Jeratsch, Ulli
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Bioinformat & Syst Biol, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Breier, Michaela
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Adamski, Jerzy
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Genome Anal Ctr, Inst Expt Genet, D-85764 Neuherberg, Germany
Tech Univ Munich, Lehrstuhl Expt Genet, D-80290 Munich, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Koenig, Wolfgang
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, D-89069 Ulm, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Zeilinger, Sonja
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Fuchs, Christiane
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Bioinformat & Syst Biol, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Klopp, Norman
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany
Hannover Med Sch, Hanover Unified Biobank, Hannover, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Theis, Fabian J.
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Bioinformat & Syst Biol, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Wichmann, H. -Erich
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, D-85764 Neuherberg, Germany
Univ Munich, Chair Epidemiol, Inst Med Informat Biometry & Epidemiol, Munich, Germany
Univ Munich, Klinikum Grosshadern, D-80539 Munich, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Suhre, Karsten
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Bioinformat & Syst Biol, D-85764 Neuherberg, Germany
Educ City Qatar Fdn, Weill Cornell Med Coll Qatar, Dept Physiol & Biophys, Doha, Qatar Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Illig, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany
Hannover Med Sch, Hanover Unified Biobank, Hannover, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Strauch, Konstantin
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany
Univ Munich, Chair Genet Epidemiol, Inst Med Informat Biometry & Epidemiol, Munich, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Peters, Annette
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, D-85764 Neuherberg, Germany
Munich Heart Alliance, Munich, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Gieger, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Kastenmueller, Gabi
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Bioinformat & Syst Biol, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Doering, Angela
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, D-85764 Neuherberg, Germany
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, D-85764 Neuherberg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

Meisinger, Christa
论文数: 0 引用数: 0
h-index: 0
机构:
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, D-85764 Neuherberg, Germany
Cent Hosp Augsburg, Monitoring Trends & Determinants Cardiovasc Dis C, Augsburg, Germany Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, D-85764 Neuherberg, Germany
[2]
Metabolomics: from small molecules to big ideas
[J].
Baker, Monya
.
NATURE METHODS,
2011, 8 (02)
:117-121

Baker, Monya
论文数: 0 引用数: 0
h-index: 0
机构: Monya Baker is technology editor for Nature and Nature Methods,
[3]
A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
[J].
Byrne, Hannah
;
Conroy, Paul J.
;
Whisstock, James C.
;
O'Kennedy, Richard J.
.
TRENDS IN BIOTECHNOLOGY,
2013, 31 (11)
:621-632

Byrne, Hannah
论文数: 0 引用数: 0
h-index: 0
机构:
Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland

Conroy, Paul J.
论文数: 0 引用数: 0
h-index: 0
机构:
Monash Univ, Dept Biochem & Mol Biol, Fac Med Nursing & Hlth Sci, Melbourne, Vic 3800, Australia Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland

Whisstock, James C.
论文数: 0 引用数: 0
h-index: 0
机构:
Monash Univ, Dept Biochem & Mol Biol, Fac Med Nursing & Hlth Sci, Melbourne, Vic 3800, Australia Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland

O'Kennedy, Richard J.
论文数: 0 引用数: 0
h-index: 0
机构:
Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland
Dublin City Univ, Biomed Diagnost Inst, Natl Ctr Sensor Res, Dublin 9, Ireland Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland
[4]
Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media
[J].
Chong, William P. K.
;
Yusufi, Faraaz N. K.
;
Lee, Dong-Yup
;
Reddy, Satty G.
;
Wong, Niki S. C.
;
Heng, Chew Kiat
;
Yap, Miranda G. S.
;
Ho, Ying Swan
.
JOURNAL OF BIOTECHNOLOGY,
2011, 151 (02)
:218-224

Chong, William P. K.
论文数: 0 引用数: 0
h-index: 0
机构:
ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore
Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 119220, Singapore ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore

Yusufi, Faraaz N. K.
论文数: 0 引用数: 0
h-index: 0
机构:
ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore

Lee, Dong-Yup
论文数: 0 引用数: 0
h-index: 0
机构:
ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore
Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore

Reddy, Satty G.
论文数: 0 引用数: 0
h-index: 0
机构:
ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore

Wong, Niki S. C.
论文数: 0 引用数: 0
h-index: 0
机构:
ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore

Heng, Chew Kiat
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 119220, Singapore ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore

Yap, Miranda G. S.
论文数: 0 引用数: 0
h-index: 0
机构:
ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore
Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore

Ho, Ying Swan
论文数: 0 引用数: 0
h-index: 0
机构:
ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore ASTAR, Bioproc Technol Inst, Singapore 138668, Singapore
[5]
Metabolomics for high-resolution monitoring of the cellular physiological state in cell culture engineering
[J].
Chrysanthopoulos, Panagiotis K.
;
Goudar, Chetan T.
;
Klapa, Maria I.
.
METABOLIC ENGINEERING,
2010, 12 (03)
:212-222

Chrysanthopoulos, Panagiotis K.
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Chem Engn & High Temp Chem Proc, Metab Engn & Syst Biol Lab, Fdn Res & Technol Hellas, Patras 26504, Greece
Univ Patras, Dept Biol, Patras 26500, Greece Inst Chem Engn & High Temp Chem Proc, Metab Engn & Syst Biol Lab, Fdn Res & Technol Hellas, Patras 26504, Greece

Goudar, Chetan T.
论文数: 0 引用数: 0
h-index: 0
机构:
Bayer HealthCare LLC, Global Biol Dev, Cell Culture Dev, Berkeley, CA 94710 USA Inst Chem Engn & High Temp Chem Proc, Metab Engn & Syst Biol Lab, Fdn Res & Technol Hellas, Patras 26504, Greece

Klapa, Maria I.
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Chem Engn & High Temp Chem Proc, Metab Engn & Syst Biol Lab, Fdn Res & Technol Hellas, Patras 26504, Greece
Univ Maryland, Dept Bioengn, College Pk, MD 20742 USA
Univ Maryland, Chem & Biomol Engn Dept, College Pk, MD 20742 USA Inst Chem Engn & High Temp Chem Proc, Metab Engn & Syst Biol Lab, Fdn Res & Technol Hellas, Patras 26504, Greece
[6]
Metabolite profiling of CHO cells with different growth characteristics
[J].
Dietmair, Stefanie
;
Hodson, Mark P.
;
Quek, Lake-Ee
;
Timmins, Nicholas E.
;
Chrysanthopoulos, Panagiotis
;
Jacob, Shana S.
;
Gray, Peter
;
Nielsen, Lars K.
.
BIOTECHNOLOGY AND BIOENGINEERING,
2012, 109 (06)
:1404-1414

Dietmair, Stefanie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, AIBN, Brisbane, Qld 4072, Australia Univ Queensland, AIBN, Brisbane, Qld 4072, Australia

Hodson, Mark P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, AIBN, Brisbane, Qld 4072, Australia Univ Queensland, AIBN, Brisbane, Qld 4072, Australia

Quek, Lake-Ee
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, AIBN, Brisbane, Qld 4072, Australia Univ Queensland, AIBN, Brisbane, Qld 4072, Australia

Timmins, Nicholas E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, AIBN, Brisbane, Qld 4072, Australia
Ctr Commercializat Regenerat Med, Toronto, ON M5G 1L5, Canada Univ Queensland, AIBN, Brisbane, Qld 4072, Australia

Chrysanthopoulos, Panagiotis
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, AIBN, Brisbane, Qld 4072, Australia Univ Queensland, AIBN, Brisbane, Qld 4072, Australia

Jacob, Shana S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, AIBN, Brisbane, Qld 4072, Australia Univ Queensland, AIBN, Brisbane, Qld 4072, Australia

Gray, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, AIBN, Brisbane, Qld 4072, Australia Univ Queensland, AIBN, Brisbane, Qld 4072, Australia

Nielsen, Lars K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, AIBN, Brisbane, Qld 4072, Australia Univ Queensland, AIBN, Brisbane, Qld 4072, Australia
[7]
Benchmarking biotech and pharmaceutical product development
[J].
Drakeman, Donald L.
.
NATURE BIOTECHNOLOGY,
2014, 32 (07)
:621-625

Drakeman, Donald L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Cambridge, Ctr Hlth Leadership & Enterprise, Judge Business Sch, Cambridge, England
Advent Venture Partners, London, England Univ Cambridge, Ctr Hlth Leadership & Enterprise, Judge Business Sch, Cambridge, England
[8]
Logistic equations effectively model mammalian cell batch and fed-batch kinetics by logically constraining the fit
[J].
Goudar, CT
;
Joeris, K
;
Konstantinov, KB
;
Piret, JM
.
BIOTECHNOLOGY PROGRESS,
2005, 21 (04)
:1109-1118

Goudar, CT
论文数: 0 引用数: 0
h-index: 0
机构: Bayer HealthCare, Biol Prod Div, Proc & Technol Dev, Berkeley, CA 94710 USA

Joeris, K
论文数: 0 引用数: 0
h-index: 0
机构: Bayer HealthCare, Biol Prod Div, Proc & Technol Dev, Berkeley, CA 94710 USA

Konstantinov, KB
论文数: 0 引用数: 0
h-index: 0
机构: Bayer HealthCare, Biol Prod Div, Proc & Technol Dev, Berkeley, CA 94710 USA

Piret, JM
论文数: 0 引用数: 0
h-index: 0
机构: Bayer HealthCare, Biol Prod Div, Proc & Technol Dev, Berkeley, CA 94710 USA
[9]
Metabolomics-based methods for early disease diagnostics
[J].
Gowda, G. A. Nagana
;
Zhang, Shucha
;
Gu, Haiwei
;
Asiago, Vincent
;
Shanaiah, Narasimhamurthy
;
Raftery, Daniel
.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS,
2008, 8 (05)
:617-633

Gowda, G. A. Nagana
论文数: 0 引用数: 0
h-index: 0
机构:
Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

Zhang, Shucha
论文数: 0 引用数: 0
h-index: 0
机构:
Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

Gu, Haiwei
论文数: 0 引用数: 0
h-index: 0
机构:
Purdue Univ, Dept Phys, W Lafayette, IN 47907 USA Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

Asiago, Vincent
论文数: 0 引用数: 0
h-index: 0
机构:
Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

Shanaiah, Narasimhamurthy
论文数: 0 引用数: 0
h-index: 0
机构:
Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

Raftery, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
[10]
A PROOF OF THE CONJECTURE THAT THE TUKEY-KRAMER MULTIPLE COMPARISONS PROCEDURE IS CONSERVATIVE
[J].
HAYTER, AJ
.
ANNALS OF STATISTICS,
1984, 12 (01)
:61-75

HAYTER, AJ
论文数: 0 引用数: 0
h-index: 0