Biological X-ray absorption spectroscopy (BioXAS): a valuable tool for the study of trace elements in the life sciences

被引：40

作者：

Strange, Richard W. ^{[1
]}

Feiters, Martin C. ^{[2
]}

机构：

[1] Univ Liverpool, Mol Biophys Grp, Sch Biol Sci, Liverpool L69 7ZB, Merseyside, England

[2] Radboud Univ Nijmegen, Dept Organ Chem, Inst Mol & Mat, NL-6565 AJ Nijmegen, Netherlands

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2008年 / 18卷 / 05期

关键词：

D O I：

10.1016/j.sbi.2008.06.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using X-ray absorption spectroscopy (XAS) the binding modes (type and number of ligands, distances and geometry) and oxidation states of metals and other trace elements in crystalline as well as non-crystalline samples can be revealed. The method may be applied to biological systems as a 'standalone' technique, but it is particularly powerful when used alongside other X-ray and spectroscopic techniques and computational approaches. In this review, we highlight how biological XAS is being used in concert with crystallography, spectroscopy and computational chemistry to study metalloproteins in crystals, and report recent applications on relatively rare trace elements utilised by living organisms and metals involved in neurodegenerative diseases.

引用

页码：609 / 616

页数：8

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