Innovative strategies in living donor kidney transplantation

被引:30
作者
Segev, Dorry L. [1 ]
机构
[1] Johns Hopkins Univ, Dept Surg, Sch Med, Baltimore, MD 21205 USA
关键词
ANTIBODY-MEDIATED REJECTION; PAIRED DONATION; RENAL-TRANSPLANTATION; UNITED-STATES; NEPHRECTOMY; OUTCOMES; DESENSITIZATION; RECIPIENTS; SURVIVAL; EXCHANGE;
D O I
10.1038/nrneph.2012.82
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
In an effort to increase living donor transplantation while minimizing risk and morbidity, recent advances have been made in surgical technique, kidney paired donation, desensitization, identification of living donors and research into living donor outcomes. Single-port nephrectomy and vaginal extraction have reduced donor nephrectomy incision size. Transport of live donor kidneys has reduced geographic barriers to kidney paired donation, and participation of compatible pairs and nondirected donors has increased match opportunities for incompatible pairs participating in this modality. ABO-incompatible transplantation can now be successfully performed without high-intensity immunomodulation, and HLA-incompatible transplantation has been shown in a large single-center study to provide profound survival benefit compared with waiting for a compatible donor. Complement inhibition is an exciting, emerging approach that may facilitate incompatible transplantation and treat antibody-mediated rejection. Educational and communications interventions are proving valuable in helping patients find living donors, and large studies continue to provide reassurance to carefully screened living donors that risks are very low. As living donors are critical to addressing the profound organ shortage, efforts to increase living donation remain important. Segev, D. L. Nat. Rev. Nephrol. 8, 332-338 (2012); published online 1 May 2012; doi: 10.1038/nrneph.2012.82
引用
收藏
页码:332 / 338
页数:7
相关论文
共 50 条
  • [21] Living-donor kidney transplantation
    Mehrabi, A.
    Fonouni, H.
    Golriz, M.
    Schmied, B.
    Tahmasbirad, M.
    Weitz, J.
    Buechler, M. W.
    Zeier, M.
    Schmidt, J.
    CHIRURG, 2010, 81 (09): : 794 - +
  • [22] Guidelines for living donor kidney transplantation
    Frutos, Miguel Angel
    Crespo, Marta
    de la Oliva Valentin, Maria
    Alonso-Melgar, Angel
    Alonso, Juana
    Fernandez, Constantino
    Garcia-Erauzkin, Gorka
    Gonzalez, Esther
    Gonzalez-Rinne, Ana M.
    Guirado, Lluis
    Gutierrez-Dalmau, Alex
    Huguet, Jorge
    Lopez del Moral, Jose Luis
    Musquera, Mireia
    Paredes, David
    Redondo, Dolores
    Revuelta, Ignacio
    Van-der Hofstadt, Carlos J.
    Alcaraz, Antonio
    Alonso-Hernandez, Angel
    Alonso, Manuel
    Bernabeu, Purificacion
    Bernal, Gabriel
    Breda, Alberto
    Cabello, Mercedes
    Luis Caro-Oleas, Jose
    Cid, Joan
    Diekmann, Fritz
    Espinosa, Laura
    Facundo, Carme
    Garcia, Marta
    Gil-Vernet, Salvador
    Lozano, Miquel
    Mahillo, Beatriz
    Jose Martinez, Maria
    Miranda, Blanca
    Oppenheimer, Federico
    Palou, Eduard
    Jose Perez-Saez, Maria
    Peri, Lluis
    Rodriguez, Oscar
    Santiago, Carlos
    Tabernero, Guadalupe
    Hernandez, Domingo
    Dominguez-Gil, Beatriz
    Pascual, Julio
    NEFROLOGIA, 2022, 42 : 1 - 128
  • [23] Donor Perspectives in Living Kidney Transplantation
    Rana, T. A.
    Akoh, J. A.
    DIALYSIS & TRANSPLANTATION, 2010, 39 (05) : 208 - 213
  • [24] Living unrelated donor kidney transplantation
    Gjertson, DW
    Cecka, JM
    KIDNEY INTERNATIONAL, 2000, 58 (02) : 491 - 499
  • [25] Delayed graft function in living donor kidney transplantation
    Khan, Taqi
    Kamal, Suhaib
    Koshaji, Basem
    Akhtar, Faheem
    ANNALS OF TRANSPLANTATION, 2013, 18 : 434 - 435
  • [26] Preemptive Deceased Donor Kidney Transplantation: Considerations of Equity and Utility
    Grams, Morgan E.
    Chen, B. Po-Han
    Coresh, Josef
    Segev, Dorry L.
    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 8 (04): : 575 - 582
  • [27] Strategies to increase the donor pool and access to kidney transplantation: an international perspective
    Maggiore, Umberto
    Oberbauer, Rainer
    Pascual, Julio
    Viklicky, Ondrej
    Dudley, Chris
    Budde, Klemens
    Sorensen, Soren Schwartz
    Hazzan, Marc
    Klinger, Marian
    Abramowicz, Daniel
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2015, 30 (02) : 217 - 222
  • [28] Improving HLA matching in living donor kidney transplantation using kidney paired exchange program
    Tafulo, Sandra
    Malheiro, Jorge
    Dias, Leonidio
    Lobato, Luisa
    Ramalhete, Luis
    Martinho, Antonio
    Bolotinha, Catarina
    Costa, Rita
    Ivo, Margarida
    TRANSPLANT IMMUNOLOGY, 2020, 62
  • [29] Simultaneous Pancreas-Kidney Transplantation Versus Living Donor Kidney Transplantation Alone: an Outcome-Driven Choice?
    Venkatanarasimhamoorthy, Vishnu Swaroop
    Barlow, Adam D.
    CURRENT DIABETES REPORTS, 2018, 18 (09) : 67
  • [30] Center-Level Factors and Racial Disparities in Living Donor Kidney Transplantation
    Hall, Erin C.
    James, Nathan T.
    Wang, Jacqueline M. Garonzik
    Berger, Jonathan C.
    Montgomery, Robert A.
    Dagher, Nabil N.
    Desai, Niraj M.
    Segev, Dorry L.
    AMERICAN JOURNAL OF KIDNEY DISEASES, 2012, 59 (06) : 849 - 857