Phenolics with anti-HSV and anti-HIV activities from Artocarpus gomezianus , Mallotus pallidus , and Triphasia trifolia

被引：22
作者：
Likhitwitayawuid, K [1 ]
Supudompol, B
Sritularak, B
Lipipun, V
Rapp, K
Schinazi, RF
机构：
[1] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Microbiol, Bangkok, Thailand
[3] Emory Univ, Sch Med, Vet Affairs Med Ctr, Decatur, GA 30033 USA
[4] Emory Univ, Sch Med, Dept Pediat, Decatur, GA 30033 USA
来源：
PHARMACEUTICAL BIOLOGY | 2005年 / 43卷 / 08期
关键词：
Artocarpus gomezianus; bis-hydroxyphenyl; coumarin; flavonoid; herpes; HIV; Mallotus pallidus; phenolic; phloroglucinol; Triphasia trifolia;
D O I：
10.1080/13880200500383058
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A total of 25 phenolic compounds were studied for their inhibitory effects against herpes simplex virus (HSV)-1, HSV-2, and human immunodeficiency virus (HIV)-1. These include five flavonoids (1-5) and two dimeric stilbenes (6,7) from Artocarpus gomezianus Wall. ex trec., five phloroglucinol derivatives (8-12) from Mallotus pallidus (Airy Shaw) Airy Shaw, and 13 courmarins (13-25) from Triphasia trifolia (Burm.f.) P. Wilson. The data obtained in this study suggest the bis-hydroxyphenyl structure as a potential target for anti-HSV and HIV drugs development.
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收藏
页码：651 / 657
页数：7
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