Activation of Proteinase-Activated Receptor 2 Prevents Apoptosis of Lung Cancer Cells

被引：18

作者：

Huang, Shao-hong ^{[1
]}

Li, Yun ^{[1
]}

Chen, Hui-guo ^{[1
]}

Rong, Jian ^{[2
]}

Ye, Sheng ^{[3
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Cardiothorac Surg, Guangzhou 510080, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Anesthesiol, Guangzhou 510080, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Med Oncol, Guangzhou 510080, Guangdong, Peoples R China

来源：

CANCER INVESTIGATION | 2013年 / 31卷 / 09期

关键词：

Lung cancer; Tryptase; Protease-activated receptor 2; Apoptosis; Epidermal growth factor receptor; MECHANISMS; TRYPTASE; THERAPY;

D O I：

10.3109/07357907.2013.845674

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The therapeutics of lung cancer (LC) is unsatisfactory. The pathogenesis of LC remains unclear. Protease-activated receptors (PAR) are involved in the immunoregulation. The present study aims to investigate the activation of PAR2 in regulation of the expression of EGFR and apoptosis of LC cells. The results showed that exposure to tryptase increased EGFR expression in A549 cells and suppressed the cell apoptosis. Tryptase also decreased the expression of Bax and increased Bcl-xL levels in A549 cells. We conclude that activation of PAR2 by tryptase can decrease the ratio of Bax/Bcl-xL and reduce the LC cell line, A549 cells, and apoptosis.

引用

页码：578 / 581

页数：4

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