ORY-1001: Overcoming the Differentiation Block in AML

被引：21

作者：

Bose, Prithviraj ^{[1
]}

Konopleva, Marina Y. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

来源：

CANCER CELL | 2018年 / 33卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ACUTE MYELOID-LEUKEMIA; INHIBITION; CELLS;

D O I：

10.1016/j.ccell.2018.02.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Maes and colleagues report in vitro and in vivo findings with ORY-1001-an oral, highly potent and selective covalent small-molecule inhibitor of lysine-specific demethylase 1 (LSD1)-in development for acute myeloid leukemia (AML), as well as correlative data from two AML patients receiving ORY-1001.

引用

页码：342 / 343

页数：2

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