On the functional and structural characterization of hubs in protein-protein interaction networks

被引：39

作者：

Bertolazzi, Paola ^{[1
]}

Bock, Mary Ellen ^{[2
]}

Guerra, Concettina ^{[3
]}

机构：

[1] IASI CNR, Rome, Italy

[2] Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA

[3] Georgia Inst Technol, Coll Comp, Atlanta, GA 30332 USA

来源：

BIOTECHNOLOGY ADVANCES | 2013年 / 31卷 / 02期

关键词：

Protein-Protein interaction networks; Network topology; Hubs; Protein 3D structure; Evolution; Lethality; Structural disorder; INTRINSICALLY UNSTRUCTURED PROTEINS; EVOLUTIONARY RATE; ESSENTIAL GENES; DISORDERED PROTEINS; MULTIPLE PROTEINS; SIMPLE DEPENDENCE; SYSTEMS BIOLOGY; FLEXIBLE NETS; YEAST; ESSENTIALITY;

D O I：

10.1016/j.biotechadv.2012.12.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A number of interesting issues have been addressed on biological networks about their global and local properties. The connection between the topological properties of proteins in Protein-Protein Interaction (PPI) networks and their biological relevance has been investigated focusing on hubs, i.e. proteins with a large number of interacting partners. We will survey the literature trying to answer the following questions: Do hub proteins have special biological properties? Do they tend to be more essential than non-hub proteins? Are they more evolutionarily conserved? Do they play a central role in modular organization of the protein interaction network? Are there structural properties that characterize hub proteins? (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：274 / 286

页数：13

共 120 条

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