Androgen action and metabolism in prostate cancer

被引：137
作者：
Green, Sean M. [1 ]
Mostaghel, Elahe A. [2 ]
Nelson, Peter S. [1 ]
机构：
[1] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA
[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2012年 / 360卷 / 1-2期
关键词：
Castration resistant; Androgen receptor; Splice variant; Steroidogenesis; Intracrine; Steroid transport; RECEPTOR GENE AMPLIFICATION; INHIBITOR ABIRATERONE ACETATE; SIGNAL-TRANSDUCTION PATHWAYS; I CLINICAL-TRIAL; STROMAL CELLS; LNCAP CELLS; DEPRIVATION THERAPY; PROTEIN EXPRESSION; ANTITUMOR-ACTIVITY; ADRENAL ANDROGENS;
D O I：
10.1016/j.mce.2011.09.046
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The transcriptional programs regulated through the activity of the androgen receptor (AR) modulate normal prostate development and the maintenance of prostatic functions at maturity. AR signaling also controls key survival and growth functions operative in prostate cancer. Inhibiting the AR program remains the key target in the treatment of advanced prostate cancer, and suppressing AR also holds great potential for preventing the development or progression of early stage prostate cancer. In this review, we detail molecular mechanisms of AR activity, cellular components contributing to the maintenance of AR signaling despite AR-ligand suppression, and discuss treatment strategies designed to target components of resistance to AR-directed therapeutics. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：3 / 13
页数：11
相关论文
共 129 条
[1]   An androgen-IL-6-Stat3 autocrine loop re-routes EGF signal in prostate cancer cells [J].
Aaronson, David S. ;
Muller, Melissa ;
Neves, Susana R. ;
Chung, Wen-Chen ;
Jayaram, Gomathi ;
Iyengar, Ravi ;
Ram, Prahlad T. .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2007, 270 (1-2) :50-56
[2]   METABOLISM OF [4-14C]PROGESTERONE BY HYPERTROPHIC AND CARCINOMATOUS HUMAN PROSTATE TISSUE [J].
ACEVEDO, HF ;
GOLDZIEHER, JW .
BIOCHIMICA ET BIOPHYSICA ACTA, 1965, 111 (01) :294-+
[3]   Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression [J].
Agoulnik, IU ;
Vaid, A ;
Bingman, WE ;
Erdeme, H ;
Frolov, A ;
Smith, CL ;
Ayala, G ;
Ittmann, MM ;
Weigel, NL .
CANCER RESEARCH, 2005, 65 (17) :7959-7967
[4]   Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor [J].
Andersen, Raymond J. ;
Mawji, Nasrin R. ;
Wang, Jun ;
Wang, Gang ;
Haile, Simon ;
Myung, Jae-Kyung ;
Watt, Kate ;
Tam, Teresa ;
Yang, Yu Chi ;
Banuelos, Carmen A. ;
Williams, David E. ;
McEwan, Iain J. ;
Wang, Yuzhou ;
Sadar, Marianne D. .
CANCER CELL, 2010, 17 (06) :535-546
[5]  
[Anonymous], 2010 GEN CANC S
[6]   Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells [J].
Arnold, Julia I. ;
Gray, Nora E. ;
Jacobowitz, Ketzela ;
Viswanathan, Lavanya ;
Cheung, Pui W. ;
McFann, Kimberly K. ;
Le, Hanh ;
Blackman, Marc R. .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2008, 111 (3-5) :240-246
[7]   Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven [J].
Attard, Gerhardt ;
Reid, Alison H. M. ;
Yap, Timothy A. ;
Raynaud, Florence ;
Dowsett, Mitch ;
Settatree, Sarah ;
Barrett, Mary ;
Parker, Christopher ;
Martins, Vanessa ;
Folkerd, Elizabeth ;
Clark, Jeremy ;
Cooper, Colin S. ;
Kaye, Stan B. ;
Dearnaley, David ;
Lee, Gloria ;
de Bono, Johann S. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (28) :4563-4571
[8]   Selective Inhibition of CYP17 With Abiraterone Acetate Is Highly Active in the Treatment of Castration-Resistant Prostate Cancer [J].
Attard, Gerhardt ;
Reid, Alison H. M. ;
A'Hern, Roger ;
Parker, Christopher ;
Oommen, Nikhil Babu ;
Folkerd, Elizabeth ;
Messiou, Christina ;
Molife, L. Rhoda ;
Maier, Gal ;
Thompson, Emilda ;
Olmos, David ;
Sinha, Rajesh ;
Lee, Gloria ;
Dowsett, Mitch ;
Kaye, Stan B. ;
Dearnaley, David ;
Kheoh, Thian ;
Molina, Arturo ;
de Bono, Johann S. .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (23) :3742-3748
[9]   The backdoor pathway to dihydrotestosterone [J].
Auchus, RJ .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2004, 15 (09) :432-438
[10]  
Bakin RE, 2003, CANCER RES, V63, P1981
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