Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes

被引：110
作者：
Lee, Jongsoon [1 ]
机构：
[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02115 USA
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2013年 / 36卷 / 02期
关键词：
Adipose tissue macrophage (ATM); Insulin resistance; Obesity; Inflammation; NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; C-REACTIVE PROTEIN; FACTOR-KAPPA-B; FREE FATTY-ACIDS; SKELETAL-MUSCLE; 3T3-L1; ADIPOCYTES; BLOOD MONOCYTES; TNF-ALPHA; IKK-BETA;
D O I：
10.1007/s12272-013-0023-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
It has been increasingly accepted that chronic subacute inflammation plays an important role in the development of insulin resistance and type 2 Diabetes in animals and humans. Particularly supporting this is that suppression of systemic inflammation in type 2 Diabetes improves glycemic control; this also points to a new potential therapeutic target for the treatment of type 2 Diabetes. Recent studies strongly suggest that obesity-induced inflammation is mainly mediated by tissue resident immune cells, with particular attention being focused on adipose tissue macrophages (ATMs). This review delineates the current progress made in understanding obesity-induced inflammation and the roles ATMs play in this process.
引用
收藏
页码：208 / 222
页数：15
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