Decreased sensory cortical excitability after 1 Hz rTMS over the ipsilateral primary motor cortex

被引:110
作者
Enomoto, H [1 ]
Ugawa, Y [1 ]
Hanajima, R [1 ]
Yuasa, K [1 ]
Mochizuki, H [1 ]
Terao, Y [1 ]
Shiio, Y [1 ]
Furubayashi, T [1 ]
Iwata, NK [1 ]
Kanazawa, I [1 ]
机构
[1] Univ Tokyo, Grad Sch Med, Div Neurosci, Dept Neurol,Bunkyo Ku, Tokyo 1138655, Japan
关键词
sensory cortex; motor cortex; repetitive transcranial magnetic stimulation; sensory evoked potential;
D O I
10.1016/S1388-2457(01)00667-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives: To study changes in the excitability of the sensory cortex by repetitive transcranial magnetic stimulation (rTMS) in humans. Methods: Somatosensory evoked potentials (SEPs) and antidromic sensory nerve action potentials (SNAPs) were elicited by right median nerve stimulation at the wrist before and after low frequency (I Hz) rTMS over the left motor cortex, lateral premotor cortex, sensory cortex, and also after sham stimulation. The intensity of rTMS was fixed at 1.1 times the active motor threshold at the hand area of motor cortex. Results: N20 peak (N20p)-P25 and P25-N33 amplitudes were suppressed after rTMS over the motor cortex, whereas the N20 onset (N20o)-N20p and SNAP amplitudes were not affected. They recovered to the baseline about 100 min after the rTMS. rTMS over the premotor cortex or sensory cortex or sham stimulation had no suppressive effect on SEPs. Conclusions: The reduction of N20p-P25 and P25-N33 components without any changes of N20o-N20p amplitude suggests that the suppression occurs in the sensory cortex. rTMS (I Hz) of the motor cortex induces a long-lasting suppression of the ipsilateral sensory cortex even at an intensity as low as 1.1 times the active motor threshold. probably via cortico-cortical pathways between motor and sensory cortex. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:2154 / 2158
页数:5
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