Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Complex Interaction of Drugs, Viruses and the Immune System

被引：0

作者：

Criado, Paulo R. ^{[1
]}

Avancini, Joao ^{[1
]}

Santi, Claudia G. ^{[1
]}

Amoedo Medrado, Ana T. ^{[2
]}

Rodrigues, Carlos E. ^{[3
]}

de Carvalho, Jozelio F. ^{[4
]}

机构：

[1] Univ Sao Paulo, Fac Med, Hosp Clin, Dept Dermatol, Sao Paulo, Brazil

[2] Inst Med Especializada IMME, Feira De Santana, BA, Brazil

[3] Univ Fortaleza Unifor, Dept Med, Fortaleza, Ceara, Brazil

[4] Univ Fed Bahia, Sch Med, Hosp Univ Prof Edgard Santos, Div Rheumatol, Salvador, BA, Brazil

来源：

ISRAEL MEDICAL ASSOCIATION JOURNAL | 2012年 / 14卷 / 09期

关键词：

drug reaction with eosinophilia and systemic symptoms (DRESS syndrome); drug-induced hypersensitivity syndrome (DIHS); exanthema; herpes virus; hepatitis; nephritis; ANTICONVULSANT-HYPERSENSITIVITY-SYNDROME; HUMAN-HERPESVIRUS-6; REACTIVATION; T-CELLS; CARBAMAZEPINE; ASSOCIATION; INFECTION; ALLERGY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The DRESS syndrome (drug reaction with eosinophilia and systemic symptoms), also known as DIHS (drug-induced hypersensitivity syndrome), presents clinically as an extensive mucocutaneous rash, accompanied by fever, lymphadenopathy, hepatitis, hematologic abnormalities with eosinophilia and atypical lymphocytes, and may involve other organs with eosinophilic infiltration, producing damage in several systems, especially kidney, heart, lungs, and pancreas. The pathogenesis is related to specific drugs (especially the aromatic anticonvulsants), altered immune response, sequential reactivation of herpes virus, and association with some HLA alleles. Glucocorticoids are the basis for the treatment of the syndrome, which may be given with intravenous immunoglobulin and, in selected cases, ganciclovir. This article reviews current concepts regarding the interaction of drugs, viruses and immune responses during this complex adverse-drug reaction.

引用

页码：577 / 582

页数：6

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