The role of specific binding in human serum albumin adsorption to self-assembled monolayers

被引：28

作者：

Choi, EJ ^{[1
]}

Foster, MD ^{[1
]}

机构：

[1] Univ Akron, Maurice Morton Inst Polymer Sci, Akron, OH 44325 USA

来源：

LANGMUIR | 2002年 / 18卷 / 02期

关键词：

D O I：

10.1021/la010964j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The role of specific binding in human serum albumin (HSA) adsorption to self-assembled monolayers (SAM) was studied using X-ray reflectometry. HSA is the most abundant protein in human blood and it has several strong hydrophobic binding sites for fatty acid molecules. It was found that when the binding pockets of HSA are empty, it binds more tenaciously to a loosely packed SAM than to a densely packed SAM.

引用

页码：557 / 561

页数：5

共 32 条

[1]

ANDRADE JD, 1985, SURFACE INTERFACIAL, V2, P1

[2] Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin [J].

Bhattacharya, AA ;

Grüne, T ;

Curry, S .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 303 (05) :721-732

[3] THERMALLY INDUCED DISORDER IN ORGANIZED ORGANIC MONOLAYERS ON SOLID SUBSTRATES [J].

COHEN, SR ;

NAAMAN, R ;

SAGIV, J .

JOURNAL OF PHYSICAL CHEMISTRY, 1986, 90 (14) :3054-3056

[4] Fatty acid binding to human serum albumin: new insights from crystallographic studies [J].

Curry, S ;

Brick, P ;

Franks, NP .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1999, 1441 (2-3) :131-140

[5] INFLUENCE OF ENDOGENOUS ALBUMIN BINDING ON BLOOD-MATERIAL INTERACTIONS [J].

EBERHART, RC ;

MUNRO, MS ;

FRAUTSCHI, JR ;

LUBIN, M ;

CLUBB, FJ ;

MILLER, CW ;

SEVASTIANOV, VI .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 516 :78-95

[6]

EBERHART RC, 1987, ACS SYM SER, V343, pCH24

[7] X-RAY-SCATTERING METHODS FOR THE STUDY OF POLYMER INTERFACES [J].

FOSTER, MD .

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY, 1993, 24 (03) :179-241

[8]

FRAUTSCHI JR, 1983, T AM SOC ART INT ORG, V29, P242

[9]

HANSON S, 1996, BIOMATERIALS SCI, P228

[10] STRUCTURES AND STABILITIES OF ADSORBED PROTEINS [J].

HAYNES, CA ;

NORDE, W .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1995, 169 (02) :313-328

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