Chemistry of Tricyclic-based Heterocycles as Useful Scaffolds for Phosphodiesterase 10A Ligands

被引：2

作者：

Asproni, Battistina ^{[1
]}

Dore, Antonio ^{[1
]}

Murineddu, Gabriele ^{[1
]}

Pinna, Gerard Aime ^{[1
]}

机构：

[1] Dept Chem & Pharm, I-07100 Sassari, Italy

来源：

MINI-REVIEWS IN ORGANIC CHEMISTRY | 2013年 / 10卷 / 02期

关键词：

Linear and angular tricyclic-based heterocycles; synthetic procedures; PDE10A activity; ORALLY-ACTIVE PYRAZOLOQUINOLINES; PDE10A INHIBITORS; DISCOVERY; POTENT; HYDROLYZES; SERIES; CAMP; CNS;

D O I：

10.2174/1570193X11310020003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The discovery of phosphodiesterase 10A (PDE10A) enzyme ligands as therapeutic agents in the treatment of central nervous system diseases, especially schizophrenia and Huntington's disease nowadays is a competitive field developing rapidly, with many pharmaceutical companies involved in identifying a huge diversity of chemical scaffolds and molecular architectures for PDE10A interaction. Owing to the importance of this field, the aim of this review is to survey the chemistry and biological properties of linear and angular tricyclic-based heterocycles incorporating valid pharma-cophores for PDE10A activity.

引用

页码：123 / 140

页数：18

共 68 条

[1]

Alberti C., 1957, GAZZ CHIM ITAL, V87, P772

[2]

Altana Pharma AG, 2005, Patent No. [WO2005003130A1, 2005003130]

[3] Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors [J].

Asproni, Battistina ;

Murineddu, Gabriele ;

Pau, Amedeo ;

Pinna, Gerard A. ;

Langgard, Morten ;

Christoffersen, Claus Tornby ;

Nielsen, Jacob ;

Kehler, Jan .

BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (01) :642-649

[4]

Biotie/Wyeth, 2010, [No title captured], Patent No. [WO2010138833, 2010138833, 2010/ 138833]

[5]

Blank J, 2003, EUR J ORG CHEM, V2003, P182, DOI 10.1002/1099-0690(200301)2003:1<182::AID-EJOC182>3.0.CO

[6]

2-S

[7] Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors [J].

Chappie, Thomas A. ;

Humphrey, John M. ;

Allen, Martin P. ;

Estep, Kimberly G. ;

Fox, Carol B. ;

Lebel, Lorraine A. ;

Liras, Spiros ;

Marr, Eric S. ;

Menniti, Frank S. ;

Pandit, Jayvardhan ;

Schmidt, Christopher J. ;

Tu, Meihua ;

Williams, Robert D. ;

Yang, Feng V. .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (02) :182-185

[8] Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition [J].

Chappie, Thomas A. ;

Helal, Christopher J. ;

Hou, Xinjun .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (17) :7299-7331

[9]

Chappie T, 2009, CURR OPIN DRUG DISC, V12, P458

[10] Biochemistry and physiology of cyclic nucleotide Phosphocliesterases: Essential components in cyclic nucleotide signaling [J].

Conti, Marco ;

Beavo, Joseph .

ANNUAL REVIEW OF BIOCHEMISTRY, 2007, 76 :481-511

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