T cell antigen-receptor signal transduction

被引：205

作者：

van Leeuwen, JEM ^{[1
]}

Samelson, LE ^{[1
]}

机构：

[1] NCI, Lab Cellular & Mol Biol, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(99)80040-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on. LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-C gamma 1-Ca2+ signalling pathways, TCR-induced cytoskeletal changes involve signalling through SLP-76-Vav-Nck to activate effecters of the Rho-family of GTPases. Finally, glycolipid-enriched microdomains play a crucial role in T cell activation.

引用

页码：242 / 248

页数：7

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