The Seven Pillars of Molecular Pharmacology: GPCR Research Honored with Nobel Prize for Chemistry

被引：9
作者：
Hausch, Felix [1 ]
Holsboer, Florian [1 ]
机构：
[1] Max Planck Inst Psychiat, D-80804 Munich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 49期
关键词：
G protein-coupled receptors; membrane proteins; signal transduction; structural biology; BETA-ADRENERGIC-RECEPTOR; FK506-BINDING PROTEINS 51; CRYSTAL-STRUCTURE; ARRESTIN; LIGANDS; KINASE;
D O I：
10.1002/anie.201208565
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
G protein-coupled receptors with seven transmembrane helices (see picture) are the most important drug targets in medicine. Their molecular and structural characterization has now been honored with the Nobel Prize for Chemistry to Robert J. Lefkowitz and Brian K. Kobilka. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：12172 / 12175
页数：4
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