Cinnamic Acid and Cinnamaldehyde Ameliorate Cisplatin-Induced Splenotoxicity in Rats

被引：33

作者：

Abd El-Raouf, Ola M. ^{[1
]}

El-Sayed, El-Sayed M. ^{[2
]}

Manie, Mohamed F. ^{[1
]}

机构：

[1] NODCAR, Pharmacolgy Dept, Cairo, Egypt

[2] Al Azhar Univ, Fac Pharm, Pharmacolgy & Toxicol Dept, Cairo, Egypt

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2015年 / 29卷 / 09期

关键词：

Cinnamic acid; Cinnamaldehyde; Cisplatin; Splenotoxicity; Antioxidant; INDUCED NEPHROTOXICITY; BLOOD SMEARS; LIPOIC ACID; ACCUMULATION; RESISTANCE; STRESS; ALPHA; LIVER; MICE;

D O I：

10.1002/jbt.21715

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cinnamic acid (CA) and cinnamaldehyde (CD) are major constituents of cinnamon species. They possess various pharmacological properties of which their antioxidant activity is a prime one. This study aims to investigate potential protective effects against cisplatin (CP)-induced splenotoxicity in rats. A single dose of CP (5 mg/kg) injected i.p. caused a significant decrease in hemoglobin content (18%), total leucocytic count (46%), neutrophils (78%), and catalase (CAT) splenic activity (64%) with a marked increase in lymphocytes (26%) and splenic content of malondialdehyde (68%) and TNF- (69%) as compared with the control group. Contrarily, CA (50 mg/kg, p.o.) or CD (40 mg/kg, p.o.) administration for 7 days before CP ameliorated CP-induced splenotoxicity as indicated by mitigation of the biochemical parameters and histopathological changes. These results revealed the promising protective effects of CA and CD on CP-induced splenotoxicity in rats; an effect that might be attributed to antioxidant and anti-inflammatory activities.

引用

页码：426 / 431

页数：6

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