Poly(2-Oxazoline)s - Are They More Advantageous for Biomedical Applications Than Other Polymers?

被引：271

作者：

Sedlacek, Ondrej ^{[2
]}

Monnery, Bryn D. ^{[1
]}

Filippov, Sergey K. ^{[2
]}

Hoogenboom, Richard ^{[1
]}

Hruby, Martin ^{[2
]}

机构：

[1] Univ Ghent, Dept Organ Chem, Supramol Chem Grp, B-9000 Ghent, Belgium

[2] Acad Sci Czech Republ, Inst Macromol Chem, Vvi, CR-16206 Prague 6, Czech Republic

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2012年 / 33卷 / 19期

关键词：

biocompatibility; biological applications of polymers; physicochemical behavior; polyoxazolines; synthesis; RING-OPENING POLYMERIZATION; CRITICAL SOLUTION TEMPERATURE; DRUG-DELIVERY SYSTEMS; CYCLIC IMINO ETHERS; N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER-DOXORUBICIN; POLYION COMPLEX MICELLES; DILUTE AQUEOUS-SOLUTIONS; POLY(ETHYLENE GLYCOL); HPMA COPOLYMERS; THERMORESPONSIVE POLYMERS;

D O I：

10.1002/marc.201200453

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(2-alkyl-2-oxazoline)s are biocompatible polymers with polypeptide-isomeric structures that are attracting increasing interest as biomaterials for drug, gene, protein, and radionuclide delivery. They are, however, still relatively new in comparison to other classes of hydrophilic water-soluble polymers already established for such use, including poly(ethylene oxide), polyvinylpyrrolidone, and polymethacrylamides such as poly[N-(2-hydroxypropyl)methacrylamide]. This feature article critically compares the synthetic aspects and physicochemical and biological properties of poly(2-alkyl-2-oxazoline)s and these commonly studied polymers in terms of their suitability for biomedical applications.

引用

页码：1648 / 1662

页数：15

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