RETRACTED: Ex vivo expansion of hematopoietic stem cell by fusion protein TAT-Zfx (Retracted article. See vol. 388, pg. 465, 2009)

被引：4

作者：

Xu, Chong ^{[2
]}

Zhang, Yanbing ^{[3
]}

Jiang, Hua ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Dept Heamatol Oncol, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Lab Diagnost Ctr, Shanghai 200030, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Dept Surg, Shanghai 200030, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 379卷 / 03期

关键词：

Hematopoietic stem cell; Self-renewal; Zfx; TAT; POLYCOMB-GROUP GENES; BONE-MARROW-CELLS; IN-VIVO; TRANSDUCTION; REPOPULATION; ACTIVATION;

D O I：

10.1016/j.bbrc.2008.12.125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relative inability of hemopoietic stem cells (HSCs) to reproduce themselves (self-renew) ex vivo imposes substantial limitations on the current use of HSC transplantation. Recently, the transcription factor Zfx has been demonstrated that played an important in controlling the self-renewal of hematopoietic stem cells. Here, we reported that Zfx could enable high-level expansion of HSCs in vitro, by combination of protein transduction domain, TAT. Furthermore, we also demonstrated that expanded HSCs population retains their normal in vivo potential of pluripotency. It is thus that TAT-Zfx has the potential to expand HSCs significantly in vitro, and will have enormous clinical potentials. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：771 / 774

页数：4

共 16 条

[1] HOXB4-induced expansion of adult hematopoietic stem cells ex vivo [J].