Emerging Antimicrobial-Resistant High-Risk Klebsiella pneumoniae Clones ST307 and ST147

被引:206
作者
Peirano, Gisele [1 ,2 ]
Chen, Liang [3 ,4 ]
Kreiswirth, Barry N. [3 ,4 ]
Pitout, Johann D. D. [1 ,2 ,5 ]
机构
[1] Alberta Precis Labs, Calgary, AB, Canada
[2] Univ Calgary, Calgary, AB, Canada
[3] Hackensack Meridian Hlth Ctr Discovery & Innovat, Nutley, NJ USA
[4] Seton Hall Univ, Hackensack Meridian Sch Med, Nutley, NJ USA
[5] Univ Pretoria, Pretoria, Gauteng, South Africa
基金
美国国家卫生研究院;
关键词
antimicrobial resistance; high-risk clones; CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE; MOLECULAR EPIDEMIOLOGY; ESCHERICHIA-COLI; CARE HOSPITALS; SEQUENCE TYPES; SPREAD; DISSEMINATION; SURVEILLANCE; OUTBREAK; EXPANSION;
D O I
10.1128/AAC.01148-20
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
There is an enormous global public health burden due to antimicrobial-resistant (AMR) Klebsiella pneumoniae high-risk clones. K. pneumoniae ST307 and 5T147 are recent additions to the family of successful clones in the species. Both clones likely emerged in Europe during the early to mid-1990s and, in a relatively short time, became prominent global pathogens, spreading to all continents (with the exception of Antarctica). ST307 and ST147 consist of multiple clades/clusters and are associated with various carbapenemases (i.e., KPCs, NDMs, OXA-48-like, and VIMs). ST307 is endemic in Italy, Colombia, the United States (Texas), and South Africa, while ST147 is endemic in India, Italy, Greece, and certain North African countries. Both clones have been introduced into regions of nonendemicity, leading to worldwide nosocomial outbreaks. Genomic studies showed ST307 and ST147 contain identical gyrA and parC mutations and likely obtained plasmids with bla(CTX-M-15) during the early to mid-2000s, which aided in their global distribution. ST307 and ST147 then acquired plasmids with various carbapenemases during the late 2000s, establishing themselves as important AMR pathogens in certain regions. Both clones are likely underreported due to restricted detection methodologies. ST307 and ST147 have the ability to become major threats to public health due to their worldwide distribution, ability to cause serious infections, and association with AMR, including panresistance. The medical community at large, especially those concerned with antimicrobial resistance, should be aware of the looming threat posed by emerging AMR high-risk clones such as K. pneumoniae ST307 and ST147.
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页数:14
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共 90 条
[1]  
Avgoulea K, 2018, ANTIMICROB AGENTS CH, V62, DOI [10.1128/AAC.02457-17, 10.1128/aac.02457-17]
[2]   Successful control of an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae ST307 outbreak in a neonatal intensive care unit [J].
Baek, Eun-Hwa ;
Kim, Se-Eun ;
Kim, Sunjoo ;
Lee, Seungjun ;
Cho, Oh-Hyun ;
Hong, Sun In ;
Shin, Jeong Hwan ;
Hwang, Inyeong .
BMC INFECTIOUS DISEASES, 2020, 20 (01)
[3]   Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens [J].
Baker, Stephen ;
Thomson, Nicholas ;
Weill, Francois-Xavier ;
Holt, Kathryn E. .
SCIENCE, 2018, 360 (6390) :733-738
[4]   Emergence of pan-resistance in KPC-2 carbapenemase-producing Klebsiella pneumoniae in Crete, Greece: a close call [J].
Bathoorn, E. ;
Tsioutis, C. ;
Voorham, J. M. da Silva ;
Scoulica, E. V. ;
Ioannidou, E. ;
Zhou, K. ;
Rossen, J. W. ;
Gikas, A. ;
Friedrich, A. W. ;
Grundmann, H. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016, 71 (05) :1207-1212
[5]   Molecular and microbiological report of a hospital outbreak of NDM-1-carrying Enterobacteriaceae in Mexico [J].
Bocanegra-Ibarias, Paola ;
Garza-Gonzalez, Elvira ;
Morfin-Otero, Rayo ;
Barrios, Humberto ;
Villarreal-Trevino, Licet ;
Rodriguez-Noriega, Eduardo ;
Garza-Ramos, Ulises ;
Petersen-Morfin, Santiago ;
Silva-Sanchez, Jesus .
PLOS ONE, 2017, 12 (06)
[6]   An Update of the Evolving Epidemic of blaKPC Carrying Klebsiella pneumoniae in Sicily, Italy, 2014: Emergence of Multiple Non-ST258 Clones [J].
Bonura, Celestino ;
Giuffre, Mario ;
Aleo, Aurora ;
Fasciana, Teresa ;
Di Bernardo, Francesca ;
Stampone, Tomaso ;
Giammanco, Anna ;
Palma, Daniela Maria ;
Mammina, Caterina .
PLOS ONE, 2015, 10 (07)
[7]   An outbreak of ST307 extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae in a rehabilitation center: An unusual source and route of transmission [J].
Boonstra, Marrit B. ;
Spijkerman, Dorien C. M. ;
in't Holt, Anne F. Voor ;
van der Laan, Rob J. ;
Bode, Lonneke G. M. ;
van Vianen, Wim ;
Klaassen, Corne H. W. ;
Vos, Margreet C. ;
Severin, Juliette A. .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2020, 41 (01) :31-36
[8]   Rapid Expansion of KPC-2-Producing Klebsiella pneumoniae Isolates in Two Texas Hospitals due to Clonal Spread of ST258 and ST307 Lineages [J].
Castanheira, Mariana ;
Farrell, Sarah E. ;
Wanger, Audrey ;
Rolston, Kenneth V. ;
Jones, Ronald N. ;
Mendes, Rodrigo E. .
MICROBIAL DRUG RESISTANCE, 2013, 19 (04) :295-297
[9]   Changing epidemiology of KPC-producing Klebsiella pneumoniae in Argentina: Emergence of hypermucoviscous ST25 and high-risk clone ST307 [J].
Cejas, Daniela ;
Elena, Alan ;
Guevara Nunez, Daiana ;
Sevillano Platero, Priscila ;
De Paulis, Adriana ;
Magarinos, Francisco ;
Alfonso, Claudia ;
Alejandra Berger, Maria ;
Fernandez-Canigia, Liliana ;
Gutkind, Gabriel ;
Radice, Marcela .
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2019, 18 :238-242
[10]  
Chen LPG, 2017, GENOMIC DIVERSITY GL