Design, synthesis and bioactivity evaluation of tribactam β lactamase inhibitors

被引：16
作者：
Copar, A
Prevec, T
Anzic, B
Mesar, T
Selic, L
Vilar, M
Solmajer, T
机构：
[1] Lek Dd, Res & Dev, Ljubljana 1526, Slovenia
[2] Natl Inst Chem, Ljubljana 1001, Slovenia
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 06期
关键词：
D O I：
10.1016/S0960-894X(02)00061-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Known carbapenem compounds with inhibitory effect towards P-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：971 / 975
页数：5
相关论文
共 31 条
[1]   Interactions of B-Lactamases with sanfetrinem (GV 104326) compared to those with imipenem and with oral β-lactams [J].
Babini, GS ;
Yuan, MF ;
Livermore, DM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (05) :1168-1175
[2]  
BASKER MJ, 1990, J ANTIBIOT, V3, P470
[3]  
BENNET I, 1991, J ANTIBIOT, V44, P70
[4]   KINETIC INTERACTIONS OF TAZOBACTAM WITH BETA-LACTAMASES FROM ALL MAJOR STRUCTURAL CLASSES [J].
BUSH, K ;
MACALINTAL, C ;
RASMUSSEN, BA ;
LEE, VJ ;
YANG, YJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (04) :851-858
[5]  
CHAEUK I, 1994, J ANTIBIOT, V47, P1031
[6]   A STEREOSELECTIVE SYNTHESIS OF A KEY 1-BETA-METHYLCARBAPENEM INTERMEDIATE VIA A DIASTEREOSELECTIVE DECARBOXYLATION [J].
CHOI, WB ;
CHURCHILL, HRO ;
LYNCH, JE ;
THOMPSON, AS ;
HUMPHREY, GR ;
VOLANTE, RP ;
REIDER, PJ ;
SHINKAI, I .
TETRAHEDRON LETTERS, 1994, 35 (15) :2275-2278
[7]   INVITRO EVALUATION OF BRL 42715, A NOVEL BETA-LACTAMASE INHIBITOR [J].
COLEMAN, K ;
GRIFFIN, DRJ ;
PAGE, JWJ ;
UPSHON, PA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (09) :1580-1587
[8]  
COLEMAN K, 1995, EXPERT OPIN INV DRUG, V4, P693
[9]  
COPAR A, 1998, Patent No. 9827094
[10]   SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-HETEROTRIBACTAMS [J].
DIFABIO, R ;
FERIANI, A ;
GAVIRAGHI, G ;
ROSSI, T .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (12) :1235-1240
1234