Macrophages Good guys in colorectal cancer

被引：53

作者：

Edin, Sofia ^{[1
]}

Wikberg, Maria L. ^{[1
]}

Oldenborg, Per-Arne ^{[2
]}

Palmqvist, Richard ^{[1
]}

机构：

[1] Umea Univ, Dept Med Biosci, Umea, Sweden

[2] Umea Univ, Dept Integrat Med Biol Histol & Cell Biol, Umea, Sweden

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 02期

关键词：

colorectal cancer; macrophage subtypes; CpG island methylator phenotype; microsatellite instability; prognosis; POLARIZATION;

D O I：

10.4161/onci.23038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Macrophages play a complex role in tumor progression since they can exert both tumor-preventing (M1 macrophages) and tumor-promoting (M2 macrophages) activities. In colorectal carcinoma (CRC), at odds to many other cancers, macrophage infiltration has been correlated with an improved patient survival. In a recent study, we have evaluated the distribution of M1 and M2 macrophage subtypes in CRC and their impact on patient prognosis.

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