Beneficial effect of resveratrol on cholecystokinin-induced experimental pancreatitis

被引：38

作者：

Szabolcs, A

Varga, IS

Varga, C

Berkó, A

Kaszaki, J

Letoha, T

Tiszlaviez, L

Sári, R

Lonovics, J

Takács, T

机构：

[1] Univ Szeged, Dept Med 1, Fac Med, Szeged, Hungary

[2] Univ Szeged, Biol Isotope Lab, H-6720 Szeged, Hungary

[3] Univ Szeged, Dept Comparat Physiol, Szeged, Hungary

[4] Univ Szeged, Inst Expt Surg, Szeged, Hungary

[5] Univ Szeged, Inst Chem, Szeged, Hungary

[6] Univ Szeged, Inst Pathol, Szeged, Hungary

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2006年 / 532卷 / 1-2期

基金：

匈牙利科学研究基金会;

关键词：

resveratrol pancreatitis; inflammation; scavenger; rat;

D O I：

10.1016/j.ejphar.2006.01.055

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Resveratrol is a phytoalexin with strong antioxidant and anti-inflammatory effects reaching high concentrations in red wine. The aim of our study was to test the effects of resveratrol pretreatment on cholecystokinin-octapeptide (CCK-8)-induced acute pancreatitis in rats. Animals were divided into a control group, a group treated with CCK-8 and a group receiving 10mg/kg resveratrol prior to CCK-8 administration. Resveratrol ameliorated the CCK-8-induced changes in the laboratory parameters, and reduced the histological damage in the pancreas. The drug failed to improve the pancreatic antioxidant state, but increased the amount of hepatic reduced glutathione and prevented the reduction of hepatic catalase activity. Resveratrol -induced inhibition of nuclear factor kappa B (NF-kappa B) activation or reduction of the pancreatic tumor necrosis factor-alpha (TNF-alpha) concentration could not be demonstrated. In conclusion, the beneficial effects of resveratrol on acute pancreatitis seem to be mediated by the antioxidant effect of resveratrol or by an NF-kappa B-independent anti-inflammatory mechanism. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：187 / 193

页数：7

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