High-dose cyclophosphamide for aplastic anemia and autoimmunity

被引：22

作者：

Brodsky, RA ^{[1
]}

机构：

[1] Johns Hopkins Oncol Ctr, Baltimore, MD USA

来源：

CURRENT OPINION IN ONCOLOGY | 2002年 / 14卷 / 02期

关键词：

D O I：

10.1097/00001622-200203000-00001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High-dose cyclophosphamide was developed as a conditioning regimen for allogeneic bone marrow transplantation. Later, it was discovered that high-dose cyclophosphamide spares early hematopoietic stem cells because of their relatively high levels of the enzyme aldehyde dehydrogenase; thus, high-dose cyclophosphamide is a potent immunosuppressive agent, but nonmyeloablative. Recent reports demonstrate that high-dose cyclophosphamide without bone marrow transplantation induces durable treatment-free remissions in severe aplastic anemia and a variety of other autoimmune disorders; however, there is lingering concern about the safety of this approach. (C) 2002 Lippincott Williams Wilkins, Inc.

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页码：143 / 146

页数：4

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