Relevance of carnosic acid to the treatment of several health disorders: Molecular targets and mechanisms

被引：61
作者：
Bahri, Sana [1 ,2 ]
Jameleddine, Saloua [1 ]
Shlyonsky, Vadim [2 ]
机构：
[1] Univ Tunis El Manar, Fac Med Tunis, Physiol Lab, Tunis 1007, Tunisia
[2] Univ Libre Bruxelles, Fac Med, Lab Physiopathol & Pharmacol, Brussels, Belgium
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2016年 / 84卷
关键词：
Carnosic acid; Antioxidant; Anti-inflammatory; Antitumor; ACUTE MYELOID-LEUKEMIA; ROSMARINUS-OFFICINALIS L; HUMAN NEUROBLASTOMA-CELLS; HUMAN SKIN FIBROBLASTS; AMYLOID-BETA; 1-42; HIGH-FAT-DIET; IN-VITRO; ROSEMARY EXTRACT; MITOCHONDRIAL DYSFUNCTION; CANCER CELLS;
D O I：
10.1016/j.biopha.2016.09.067
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Carnosic acid is a phenolic diterperne compound found in abundance in sage and rosemary, which are both widely used in traditional medicine. Research over the past decade indicates that carnosic acid has multiple bioactive properties including antioxidant, anti-inflammatory and anticancer activities among others. This review summarizes the current in vitro and in vivo data about the efficacy of carnosic acid in the prevention or treatment of various experimental health disorders. The analysis of the literature allows an insight into the participation of numerous signaling pathways modulated by carnosic acid, into its synergistic potential and, thus, into the divergence in cellular mechanisms of action of this molecule. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：569 / 582
页数：14
相关论文
共 113 条
[1]   The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway [J].
Arico, S ;
Petiot, A ;
Bauvy, C ;
Dubbelhuis, PF ;
Meijer, AJ ;
Codogno, P ;
Ogier-Denis, E .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) :35243-35246
[2]  
Azad N, 2011, CELL J, V13, P39
[3]   Root specific elicitation and antimicrobial activity of rosmarinic acid in hairy root cultures of Ocimum basilicum [J].
Bais, HP ;
Walker, TS ;
Schweizer, HP ;
Vivanco, JA .
PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2002, 40 (11) :983-995
[4]   Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells [J].
Barni, M. V. ;
Carlini, M. J. ;
Cafferata, E. G. ;
Puricelli, L. ;
Moreno, S. .
ONCOLOGY REPORTS, 2012, 27 (04) :1041-1048
[5]   A bioguided identification of the active compounds that contribute to the antiproliferative/cytotoxic effects of rosemary extract on colon cancer cells [J].
Borras-Linares, Isabel ;
Perez-Sanchez, Almudena ;
Lozano-Sanchez, Jesus ;
Barrajon-Catalan, Enrique ;
Arraez-Roman, David ;
Cifuentes, Alejandro ;
Micol, Vicente ;
Segura Carretero, Antonio .
FOOD AND CHEMICAL TOXICOLOGY, 2015, 80 :215-222
[6]   Carnosic Acid Prevents 6-Hydroxydopamine-Induced Cell Death in SH-SY5Y Cells via Mediation of Glutathione Synthesis [J].
Chen, Jing-Hsien ;
Ou, Hsin-Ping ;
Lin, Chia-Yuan ;
Lin, Fung-Ju ;
Wu, Chi-Rei ;
Chang, Shu-Wei ;
Tsai, Chia-Wen .
CHEMICAL RESEARCH IN TOXICOLOGY, 2012, 25 (09) :1893-1901
[7]   Carnosic acid attenuates neuropathic pain in rat through the activation of spinal sirtuin1 and down-regulation of p66shc expression [J].
Chen, Shuang-dong ;
Ji, Bin-bin ;
Yan, Yi-xiu ;
He, Xin ;
Han, Kun-yuan ;
Dai, Qin-xue ;
Zhang, Ming-xiao ;
Mo, Yun-chang ;
Wang, Jun-lu .
NEUROCHEMISTRY INTERNATIONAL, 2016, 93 :95-102
[8]   Carnosic acid from rosemary extracts:: a potential chemoprotective agent against aflatoxin B1.: An in vitro study [J].
Costa, Stefano ;
Wan, Aneli ;
Speroni, Ester ;
Cervellati, Rinaldo ;
Piva, Gianfranco ;
Prandini, Aldo ;
Guerra, Maria Clelia .
JOURNAL OF APPLIED TOXICOLOGY, 2007, 27 (02) :152-159
[9]  
Danilenko M, 2003, CANCER RES, V63, P1325
[10]   Protective effect of carnosic acid against paraquat-induced redox impairment and mitochondrial dysfunction in SH-SY5Y cells: Role for PI3K/Akt/Nrf2 pathway [J].
de Oliveira, Marcos Roberto ;
Ferreira, Gustavo Costa ;
Schuck, Patricia Fernanda .
TOXICOLOGY IN VITRO, 2016, 32 :41-54
12345678910