DIFFERENTIAL EFFECTS OF ACUTE AND REGULAR PHYSICAL EXERCISE ON COGNITION AND AFFECT

被引:149
作者
Hopkins, M. E. [1 ]
Davis, F. C. [1 ]
Vantieghem, M. R. [1 ]
Whalen, P. J. [1 ]
Bucci, D. J. [1 ]
机构
[1] Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA
关键词
BDNF; genotype; object recognition memory; mood; anxiety; stress; BDNF VAL66MET POLYMORPHISM; NEUROTROPHIC FACTOR; AEROBIC EXERCISE; CORTICAL PLASTICITY; SUBMAXIMAL EXERCISE; OLDER-ADULTS; BRAIN; MOOD; ANXIETY; MEMORY;
D O I
10.1016/j.neuroscience.2012.04.056
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of regular exercise versus a single bout of exercise on cognition, anxiety, and mood were systematically examined in healthy, sedentary young adults who were genotyped to determine brain-derived neurotrophic factor (BDNF) allelic status (i.e., Val-Val or Val66Met polymorphism). Participants were evaluated on novel object recognition (NOR) memory and a battery of mental health surveys before and after engaging in either (a) a 4-week exercise program, with exercise on the final test day, (b) a 4-week exercise program, without exercise on the final test day, (c) a single bout of exercise on the final test day, or (d) remaining sedentary between test days. Exercise enhanced object recognition memory and produced a beneficial decrease in perceived stress, but only in participants who exercised for 4 weeks including the final day of testing. In contrast, a single bout of exercise did not affect recognition memory and resulted in increased perceived stress levels. An additional novel finding was that the improvements on the NOR task were observed exclusively in participants who were homozygous for the BDNF Val allele, indicating that altered activity-dependent release of BDNF in Met allele carriers may attenuate the cognitive benefits of exercise. Importantly, exercise-induced changes in cognition were not correlated with changes in mood/anxiety, suggesting that separate neural systems mediate these effects. These data in humans mirror recent data from our group in rodents. Taken together, these current findings provide new insights into the behavioral and neural mechanisms that mediate the effects of physical exercise on memory and mental health in humans. (C) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:59 / 68
页数:10
相关论文
共 69 条
[1]  
Angevaren M, 2008, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD005381.pub2, 10.1002/14651858.CD005381.pub3]
[2]   Mood states of formerly sedentary younger and older women at weeks 1 and 10 of a moderate exercise program [J].
Annesi, JJ .
PSYCHOLOGICAL REPORTS, 2004, 94 (03) :1337-1342
[3]  
[Anonymous], 1983, MANUAL STATE TRAIT A
[4]  
Audiffren M., 2009, Exercise and Cognitive Function, P3
[5]   AN INVENTORY FOR MEASURING DEPRESSION [J].
BECK, AT ;
ERBAUGH, J ;
WARD, CH ;
MOCK, J ;
MENDELSOHN, M .
ARCHIVES OF GENERAL PSYCHIATRY, 1961, 4 (06) :561-&
[6]   Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus [J].
Berchtold, NC ;
Chinn, G ;
Chou, M ;
Kesslak, JP ;
Cotman, CW .
NEUROSCIENCE, 2005, 133 (03) :853-861
[7]   Relation of low and moderate intensity exercise with acute mood change in college joggers [J].
Berger, BG ;
Owen, DR .
PERCEPTUAL AND MOTOR SKILLS, 1998, 87 (02) :611-621
[8]   Effects of exercise training on older patients with major depression [J].
Blumenthal, JA ;
Babyak, MA ;
Moore, KA ;
Craighead, E ;
Herman, S ;
Khatri, P ;
Waugh, R ;
Napolitano, MA ;
Forman, LM ;
Appelbaum, M ;
Doraiswamy, PM ;
Krishnan, KR .
ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (19) :2349-2356
[9]   Exercise and pharmacotherapy in the treatment of major depressive disorder [J].
Blumenthal, James A. ;
Babyak, Michael A. ;
Doraiswamy, P. Murali ;
Watkins, Lana ;
Hoffman, Benson M. ;
Barbour, Krista A. ;
Herman, Steve ;
Craighead, W. Edward ;
Brosse, Alisha L. ;
Waugh, Robert ;
Hinderliter, Alan ;
Sherwood, Andrew .
PSYCHOSOMATIC MEDICINE, 2007, 69 (07) :587-596
[10]   Positive and negative affective response of trained and untrained subjects during and after aerobic exercise [J].
Boutcher, SH ;
McAuley, E ;
Courneya, KS .
AUSTRALIAN JOURNAL OF PSYCHOLOGY, 1997, 49 (01) :28-32